Strategies and Tactics in Organic Synthesis, Volume 3
Academic Press, Dec 2, 2012 - Science - 552 pages
Strategies and Tactics in Organic Synthesis, Volume 3 provides detailed accounts of interesting advances in the field of synthesis. This book discusses the tasks of multistep synthesis from finding the proper reagents, reaction, and conditions for individual steps to inventing new chemistry to fill gaps in existing synthetic methodology.
Organized into 13 chapters, this volume begins with an overview of the development of redox glycosidation strategy through ester methylenation. This text then examines the development of computer-assisted molecular modeling with applications to a wide range of problems in biological and organic chemistry. Other chapters consider the medicinal significance of ginkgo tree, which has prompted systematic studies to correlate the claimed beneficial effects of its extracts to the active principles. This book discusses as well the biological potency of pentacyclic quassinoids. The final chapter deals with the economic synthesis of a penem antibacterial.
This book is a valuable resource for chemists.
What people are saying - Write a review
We haven't found any reviews in the usual places.
CHAPTER 3 TOTAL SYNTHESIS OF GINKGOLIDE B
CHAPTER 4 SYNTHETIC STUDIES ON PENTACYCLIC QUASSINOIDS
AN INITIAL STEP TOWARD TAXOL SYNTHESIS
CHAPTER 6 THREE AND ONEHALF APPROACHES TO THE SYNTHESIS OF PEDERIN
CHAPTER 7 THE CHAMPAGNE ROUTE TO AVERMECTINS AND MILBEMYCINS
THE REST OF THE STORY
CHAPTER 9 SYNTHESIS OF CEMBRANOID NATURAL PRODUCTS BY INTRAMOLECULAR SE ADDITIONS OF ALLYLIC STANNANES TO...
CHAPTER 11 TOTAL SYNTHESIS OF THE FK506FKBP COMPLEX
CHAPTER 12 TOTAL SYNTHESIS OF FK506
CHAPTER 13 AN INDUSTRIAL PERSPECTIVE ON TOTAL SYNTHESIS PENEM ANTIBACTERIAL CP70429
Other editions - View all
acetate acid acylation addition adduct afforded aldehyde aldol alkylation allylic alcohol approach avermectin bromide carbon carbonyl Chem chemistry chiral chloride CO2R compound conformation converted Corey coupling cyclization deprotection derived desired diastereomers diol double bond electrophilic enol ether enone epoxide ester FKBP formation fragment functionality gave ginkgolide glycosidation H NMR hydride hydrolysis hydroxyl hydroxyl group intermediate intramolecular iodide isomer isomerization ketone lactone lithium MCPBA MeOH methyl methyl group methylene milbemycin mixture molecule NaBH4 natural product nucleophilic obtained olefin OTBS OTBS OTBS overall yield oxidation oxygen pederin penem precursor prepared protecting group proton quassinoids reaction reactive reagent rearrangement reduction reflux result retrosynthetic retrosynthetic analysis route Scheme selective sequence side chain silyl SO2Ph spatol stannane stereochemical stereochemistry stereoselectivity steric strategy structure substituent sulfone synthetic t-Bu taxol taxusin TBSO Tetrahedron Lett tion total synthesis trans treatment vinyl