Strategies and Tactics in Organic Synthesis, Volume 3

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Thomas Lindberg
Academic Press, Dec 2, 2012 - Science - 552 pages
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Strategies and Tactics in Organic Synthesis, Volume 3 provides detailed accounts of interesting advances in the field of synthesis. This book discusses the tasks of multistep synthesis from finding the proper reagents, reaction, and conditions for individual steps to inventing new chemistry to fill gaps in existing synthetic methodology.

Organized into 13 chapters, this volume begins with an overview of the development of redox glycosidation strategy through ester methylenation. This text then examines the development of computer-assisted molecular modeling with applications to a wide range of problems in biological and organic chemistry. Other chapters consider the medicinal significance of ginkgo tree, which has prompted systematic studies to correlate the claimed beneficial effects of its extracts to the active principles. This book discusses as well the biological potency of pentacyclic quassinoids. The final chapter deals with the economic synthesis of a penem antibacterial.

This book is a valuable resource for chemists.
 

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Contents

AN APPLICATION TO THE TOTAL SYNTHESIS OF PLEUROMUTILIN
37
CHAPTER 3 TOTAL SYNTHESIS OF GINKGOLIDE B
89
CHAPTER 4 SYNTHETIC STUDIES ON PENTACYCLIC QUASSINOIDS
121
AN INITIAL STEP TOWARD TAXOL SYNTHESIS
165
CHAPTER 6 THREE AND ONEHALF APPROACHES TO THE SYNTHESIS OF PEDERIN
199
CHAPTER 7 THE CHAMPAGNE ROUTE TO AVERMECTINS AND MILBEMYCINS
237
THE REST OF THE STORY
295
CHAPTER 9 SYNTHESIS OF CEMBRANOID NATURAL PRODUCTS BY INTRAMOLECULAR SE ADDITIONS OF ALLYLIC STANNANES TO...
347
SPATOL
381
CHAPTER 11 TOTAL SYNTHESIS OF THE FK506FKBP COMPLEX
417
CHAPTER 12 TOTAL SYNTHESIS OF FK506
463
CHAPTER 13 AN INDUSTRIAL PERSPECTIVE ON TOTAL SYNTHESIS PENEM ANTIBACTERIAL CP70429
495
Index
535
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