Stroke Genetics

Front Cover
Pankaj Sharma, James F Meschia
Springer Science & Business Media, Aug 27, 2012 - Medical - 320 pages
0 Reviews

Over the last decade there has been a substantial increase in our understanding of the genetic basis of common disorders such as stroke. Stroke Genetics is designed to give the reader an overall understanding of the genetics of complex diseases by using stroke as a paradigm. The reader will gain a comprehensive understanding of cerebrovascular genetics including the epidemiological evidence for the genetic basis of ischemic and hemorrhagic stroke, knowledge of its molecular basis from association, linkage and recent genome-wide studies, and also monogenic disorders. Finally, the legal and ethical complexities in dealing with these issues are discussed.

Stroke Genetics benefits from the contribution of renowned experts from throughout the world who have been intimately involved in unraveling the genetic etiology of stroke. Stroke Genetics is a valuable resource for neurologists, stroke physicians, hypertension specialists, internists, clinical pharmacologists and those in training, as well as researchers in the field of disease genetics.

 

What people are saying - Write a review

We haven't found any reviews in the usual places.

Contents

Chapter 1 Introduction
1
Chapter 2 Candidate Gene Association Studies in Stroke
9
Chapter 3 GenomeWide Association Studies GWAS
25
Chapter 4 The Genetics of Cerebral Aneurysms and Other Vascular Malformations
51
Chapter 5 Intracerebral Hemorrhage and Cerebral Amyloid Angiopathy
67
Chapter 6 Clinicogenetic and Pathologic Characteristics of CADASIL
81
Chapter 7 Monogenic Disorder Fabry Disease
97
Chapter 8 StrokeLike Episodes in Mitochondrial Encephalopathy Lactic Acidosis and StrokeLike Episodes MELAS
107
Chapter 10 Other Monogenetic Stroke Disorders
147
Chapter 11 White Matter Disease
171
Chapter 12 Genetics of Carotid Disease
189
Chapter 13 Genetics of Cervical Artery Dissection
207
Chapter 14 Stroke Pharmacogenetics
223
Chapter 15 Ethical Issues in the Genetics of Complex Disorders
299
Index
310
Copyright

Chapter 9 Genetics of Sickle Cell Disease and Stroke
127

Other editions - View all

Common terms and phrases

About the author (2012)

Pankaj Sharma, MD, PhD, FRCP

Reader & Consultant Neurologist

Imperial College London & Hammersmith Hospitals

London, UK

James F. Meschia, MD

Chair, Department of Neurology

Mayo Clinic Florida

Jacksonville, Florida, USA

Bibliographic information