THE SOCIETY OF CELLSFor more than 30 years, the majority of researchers has assumed quiescence to be the default state of all cells and so have provided cells in culture with 'growth factors' to stimulate them to proliferate. During this time, many putative growth factors have been identified and ever more complex mechanisms through which they could interact and stimulate cells have been proposed. However, quiescence as the default state does not make evolutionary sense and many sets of data do not support this hypothesis. In The Society of Cells, an alternative explanation for these results is proposed by applying the premise that the default state must be proliferation, with multiplication being a 'built in' property of all forms of life. |
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Sadržaj
PART | 1 |
Evolutionary perspective on the control | 14 |
The role of nutrition on the control of cell proliferation | 20 |
Autorska prava | |
Broj ostalih dijelova koji nisu prikazani: 10
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The Society of Cells: Cancer and Control of Cell Proliferation Carlos Sonnenschein,Ana M. Soto Pregled nije dostupan - 1999 |
Uobičajeni izrazi i fraze
ability activity addition adopted adult alternative animals appear become biology called cancer carcinogenesis carcinogens cause cell culture cell cycle cell death cell proliferation cellular changes Chapter chemical complexity concept considered control of cell culture default defined described differentiation effect emergent epithelial estrogen evidence example experimental experiments explain explore expression fact Finally followed function genes genetic growth factors Hence hierarchical hormones human hypothesis increase induce inhibition inhibitor interactions interpretation lack liver means mechanisms mediated medium metazoa mice models molecular multicellular organisms Nature negative neoplasia neoplastic normal notion nutrients occur oncogenes origin phase phenomena phenomenon phenotype positive premise present Press produced proliferative proposed proteins putative questions quiescence receptors regulation remains require response role serum sexual reproduction signals somatic mutation theory specific stem cells stimulate suggested target cells tion transformation tumors understanding