The Biochemical Basis of Neuropharmacology
Oxford University Press, 1986 - Architecture - 400 pages
Over the past 15 years, this volume has become widely recognized as the best on its subject, providing the liveliest and most lucid available account of neurotransmitters and their relation to drug action. The fifth edition features two new chapters on topics of current interest: molecular neurobiology and neuromodulation. In addition, all other chapters have been updated. It is a useful book for a wide variety of students and professionals, including neuroscientists, clinical neurologists, psychiatrists, psychologists, biochemists and pharmacologists.
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acetylcholine action potential activity adrenergic agents agonists amine amino acids antagonists antipsychotic antipsychotic drugs appears autoreceptors axon behavioral binding biochemical block brain catecholamine cell bodies cellular central nervous system ceptor chemical choline choline acetyltransferase cholinergic compounds concentration cortex cortical decarboxylase demonstrated depolarization DOPA dopamine dopaminergic neurons effects electron endogenous enzyme epinephrine excitatory fibers function GABA receptors gene glutamate glycine histamine hormone impulse flow increase inhibition inhibitors innervated interaction levels ligand locus coeruleus mammalian mechanism membrane metabolism metabolites methyl MHPG modulation molecular molecules monoamine oxidase mRNA muscarinic nerve cell nerve endings nerve terminal neurons neurotransmitter norepinephrine nucleus pathway peptides peripheral pharmacological phosphorylation physiological plasma possible postsynaptic presynaptic produce protein regulation release response role selective sequences serotonin somatostatin specific spinal cord stimulation structure studies substance substrate sympathetic synaptic synaptosomes synthesis techniques tion tissue transmission transmitter tryptophan turnover tyrosine hydroxylase uptake vesicles vitro vivo zyme