The Epigenome: Molecular Hide and Seek
Stephan Beck, Alexander Olek
John Wiley & Sons, Mar 6, 2006 - Science - 188 pages
This is the first book that describes the role of the Epigenome (cytosine methylation) in the interplay between nature and nurture. It focuses and stimulates interest in what will be one of the most exciting areas of post-sequencing genome science: the relationship between genetics and the environment.
Written by the most reputable authors in the field, this book is essential reading for researchers interested in the science arising from the human genome sequence and its implications on health care, industry and society.
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1 Five Not Four History and Significance of the Fifth Base
2 Epigenetic Signals Towards a Human Genome Sequence of All Five Nucleotides
3 Epi Meets Genomics Technologies for Finding and Reading the 5th Base
4 Mammalian Epigenomics Reprogramming the Genome for Development and Therapy
5 At the Controls Genomic Imprinting and the Epigenetic Regulation of Gene Expression
6 Epigenetic Trouble Human Diseases Caused by Epimutations
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abnormal Acad activity allele alterations analysis antisense transcript AP-PCR associated BAYLIN Biol bisulfite Cancer Res cell type choline chromatin chromosome cloned Colon CpG islands cytosine defects deficiency demethylation diabetes diagnostic dietary differentially methylated disease DNA methylation DNA methylation patterns DNA methyltransferase DNA sequences DNMT1 Doerfler,W domain effects embryos enzymes epigenetic inheritance epigenetic modifications epigenome epimutations factors folate folate and vitamin folic acid foreign DNA function gene expression genomic DNA genomic imprinting HDAC histone HpaII human genome hypomethylation identified Igf2 Igf2r imprinted genes inactivation inherited Issa KVLQT1 levels lymphocytes mechanisms MeCP2 methionine methy methylation-sensitive MethyLight methyltransferases micronucleus molecular mouse mutations Natl Nature Genet normal novo methylation nucleotide paternal allele patients patterns of DNA phenotype Proc promoter proteins region regulated REIK,W reprogramming RLGS role segments silencing specific studies syndrome target tion Tissue Engineering tissues tumor unmethylated uracil vitamin B12