The Flaviviruses: Pathogenesis and Immunity
Academic Press, Dec 18, 2003 - Science - 486 pages
Over 50% of known flaviviruses have been associated with human disease. The Flavivirus genus constitutes some of the most serious human pathogens including Japanese encephalitis, dengue and yellow fever. Flaviviruses are known for their complex life cycles and epidemic spread, and are considered a globally-emergent viral threat.
Pathogenesis and Immunity, the second volume of The Flaviviruses, examines the processes by which the flaviviruses cause disease, the different cytopathic effects and the associated immunopathological responses produced in their hosts.
* Comprehensive approach to the scientific disciplines needed to unravle the complexities of virus-host interactions.
* New, detailed information on the pathogenesis and immunology of the Flavivirus family.
* Descibes the technologies that have contributed to our current knowledge about the Flaviviruses.
* Identifies the major problems faced in attempting to further understand the virus-host interactions that result in disease.
* An exhaustive compendium of current and past knowledge on the Flavivirus family
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Chapter 2 Genetic Resistance to Flaviviruses
Chapter 3 Immunobiology of MosquitoBorne Encephalitic Flaviviruses
Chapter 4 Immune Modulation by Flaviviruses
Chapter 5 Mechanisms of DengueVirusInduced Cell Death
Chapter 6 Dynamics Flavivirus Infection in Mosquitoes
Chapter 7 Dynamics of Infection in Tick Vectors and at the TickHost Interface
Chapter 8 Pathogenesis of Flavivirus Encephalitis
Chapter 9 Pathogenesis and Pathophysiology of Yellow Fever
Chapter 10 Immunology and Immunopathogenesis of Dengue Disease
Chapter 11 Neutralization and AntibodyDependent Enhancement of DengueViruses
Color Plate Section
17D vaccine activity Aedes aegypti allele amino acid antigen antiviral apoptosis apoptotic arbovirus attenuation brain Brinton caspases CD4■ CD8■ T cells cell death cell response cellular clones cytokines cytotoxic dengue infections dengue virus disease domain effect enhancement Entomol epitopes factors feeding flavivirus flavivirus infection function gene genetic genome Halstead host human immune response Immunol induced infected cells inoculation interactions interferon Japanese encephalitis virus Kurane Labuda Lobigs Louis encephalitis lymphocytes macrophages McMinn mechanisms MHC class mice molecular molecules Monath monkeys mosquito mouse MuĘllbacher Murray Valley encephalitis mutations neuroinvasiveness neurons neurovirulence pathogenesis peptide phenotype protein receptor region resistant role sequence serotype specific strains studies susceptible T-cell TBE virus tick tick-borne encephalitis virus tion tissues titers uninfected upregulation vaccine vector competence viral viremia virions Virol Virology virulence virus-specific viruses viscerotropism vitro vivo West Nile virus wild-type WNV infection yellow fever virus YF virus