The Flaviviruses: Pathogenesis and Immunity

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Academic Press, Dec 18, 2003 - Medical - 486 pages
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Over 50% of known flaviviruses have been associated with human disease. The Flavivirus genus constitutes some of the most serious human pathogens including Japanese encephalitis, dengue and yellow fever. Flaviviruses are known for their complex life cycles and epidemic spread, and are considered a globally-emergent viral threat.

Pathogenesis and Immunity, the second volume of The Flaviviruses, examines the processes by which the flaviviruses cause disease, the different cytopathic effects and the associated immunopathological responses produced in their hosts.

* Comprehensive approach to the scientific disciplines needed to unravle the complexities of virus-host interactions.
* New, detailed information on the pathogenesis and immunology of the Flavivirus family.
* Descibes the technologies that have contributed to our current knowledge about the Flaviviruses.
* Identifies the major problems faced in attempting to further understand the virus-host interactions that result in disease.
* An exhaustive compendium of current and past knowledge on the Flavivirus family
 

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Contents

The Structural and Functional Basis for Flavivirus Attenuation
1
Chapter 2 Genetic Resistance to Flaviviruses
43
Chapter 3 Immunobiology of MosquitoBorne Encephalitic Flaviviruses
87
Chapter 4 Immune Modulation by Flaviviruses
121
Chapter 5 Mechanisms of DengueVirusInduced Cell Death
157
Chapter 6 Dynamics Flavivirus Infection in Mosquitoes
187
Chapter 7 Dynamics of Infection in Tick Vectors and at the TickHost Interface
233
Chapter 8 Pathogenesis of Flavivirus Encephalitis
273
Chapter 9 Pathogenesis and Pathophysiology of Yellow Fever
343
Chapter 10 Immunology and Immunopathogenesis of Dengue Disease
397
Chapter 11 Neutralization and AntibodyDependent Enhancement of DengueViruses
421
Index
469
Color Plate Section
487
Copyright

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About the author (2003)

Professor Karl Maramorosch works at Rutgers University, New Brunswick, NJ, USA.

Frederick A. Murphy, DVM, PhD, is professor, Department of Pathology, University of Texas Medical Branch (UTMB), Galveston. He holds a BS and DVM from Cornell University and a PhD from the University of California, Davis (UC Davis). Formerly he was dean and distinguished professor, School of Veterinary Medicine, and distinguished professor, School of Medicine, UC Davis. Before that he served as director of the National Center for Infectious Diseases, and director of the Division of Viral and Rickettsial Diseases, Centers for Disease Control, Atlanta. He is a member of the Institute of Medicine of the U.S. National Academy of Sciences and is a member of the German National Academy of Sciences and the Belgian Royal Academy of Medicine. He holds an honorary Doctor of Medicine and Surgery from the University of Turku, Finland; an honorary Doctor of Science from the University of Guelph, Canada; an honorary Doctor of Veterinary Medicine from the University of London, United Kingdom; an honorary Doctor of Science from University College Dublin, Ireland; the Presidential Rank Award of the U.S. Government; the PennVet World Leadership Award from the University of Pennsylvania, and the Distinguished Microbiologist Award from the American College of Veterinary Microbiologists. At UTMB, he is a member of the Institute for Human Infections and Immunity, Center for Biodefense and Emerging Infectious Diseases, Galveston National Laboratory, and McLaughlin Endowment for Infection and Immunity. His professional interests include the pathology and epidemiology of highly pathogenic viruses/viral diseases: rabies and the rabies-like viruses, arboviruses, hemorrhagic fever viruses, and other neurotropic viruses. He has been a leader in advancing the concepts of “new and emerging infectious diseases and “new and emerging zoonoses and “the threat posed by bioterrorism. Most recently, he has been working on Internet resources on the history of virology: “The Foundations of Virology at http://www.utmb.edu/virusimages/.

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