The Genetic Basis of Human CancerThis book provides a state-of-the-art overview of the fundamentals of genetics and human phenotypes, gene mutation, the Human Genome Project, and genetic imprinting. Coverage of current clinical aspects and im plications for diagnosis and treatment on a wide spectrum of active ca ncer research is also included. Thoroughly revised and updated this e dition includes two new chapters on Peutz-Jaeghers and Juvenile polypo sis syndromes. |
Contents
The Nature and Mechanisms of Human Gene Mutation | 7 |
Genomic Imprinting and Cancer | 43 |
Genes Altered by Chromosomal Translocations in Leukemia and Lymphomas | 57 |
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A-T patients abnormalities Acad Sci USA activity allele amino acid amplification analysis apoptosis associated ataxia-telangiectasia binding Bloom syndrome breakpoints breast cancer Cancer Res carcinoma cDNA cell cycle cell lines cellular chromosomal translocations clinical cloning codon colon colorectal cancer complex cyclin cytogenetic defect deletion diagnosis disease DNA repair domain encodes exon Fanconi anemia fibroblasts function gene expression genomic germ line germ-line growth factor helicase HNPCC homologous Hum Genet human identified imprinting inactivation instability interaction involved juvenile polyps lesions leukemia locus lymphoma malignant mechanism mice Mol Cell Biol molecular mouse mRNA mutations MYCN Natl Acad Sci neuroblastoma normal nucleotide oncogene paternal pathway percent phenotype phosphorylation polyposis Proc Natl Acad rearrangements receptor recombination region regulation replication retinoblastoma role sarcoma sequence signaling SMAD4 somatic specific splice studies syndrome tissue transcription factor tumor-suppressor genes tyrosine kinase Werner's syndrome wild-type Wilms tumor xeroderma pigmentosum yeast