The Genetics of Obesity

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CRC Press, Mar 28, 1994 - Medical - 256 pages
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This book provides a comprehensive compilation of the evidence available regarding the role of genetic differences in the etiology of human obesities and their health and metabolic implications. It also identifies the most promising research areas, methods, and strategies for use in future efforts to understand the genetic basis of obesities and their consequences on human health. Leading researchers in their respective fields present contributed chapters on such topics as etiology and the prevalence of obesities, nongenetic determinants of obesity and fat topography, and animal models and molecular biological technology used to delineate the genetic basis of human obesities. A major portion of the book is devoted to human genetic research and clinical observations encompassing adoption studies, twin studies, family studies, single gene effects, temporal trends and etiology heterogeneity, energy intake and food preference, energy expenditure, and susceptibility to metabolic derangements in the obese state. Future directions of research in the field are covered in the book as well.
 

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Contents

Chapter
1
Chapter 2
17
Nongenetic Determinants of Obesity and Body Fat Topography
35
Chapter 4
49
Twin Studies of Human Obesity
63
Chapter 6
79
Chapter 7
93
Chapter 13
98
Chapter 9
125
Chapter 10
135
Chapter 11
147
Chapter 12
161
Identification of Genes Underlying Polygenic Obesity in Animal Models
181
Chapter 14
199
Chapter 15
213
Index
235

Etiologic Heterogeneity and Temporal Trends
109

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Page 220 - Neel JV: Diabetes mellitus: A 'thrifty' genotype rendered detrimental by 'progress'?
Page 211 - CHOP, a novel developmentally regulated nuclear protein that dimerizes with transcription factors C/EBP and LAP and functions as a dominant-negative inhibitor of gene transcription.

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