The Influence of Common Genetic Variations in Candidate Genes on Neuropsychiatric Phenotypes 2013 Introduction: Psychiatric disorders are 'complex diseases'. A large proportion of the phenotypic variation of psychiatric conditions like schizophrenia and autism can be attributed to additive genetic effects (80%-90%). Genome-wide association studies (GWAS) comparing groups of schizophrenia patients and groups of putative healthy control subjects found multiple common single nucleotide polymorphisms (SNPs) of small effect sizes to be associated with the risk for schizophrenia. However, besides not explaining much of the variance in liability to schizophrenia, the biological and phenotypica ... |
