The Metabolic Pathway Engineering Handbook: Fundamentals

Front Cover
Christina Smolke
CRC Press, Jul 28, 2009 - Medical - 678 pages
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This first volume of the Metabolic Pathway Engineering Handbook provides an overview of metabolic pathway engineering with a look towards the future. It discusses cellular metabolism, including transport processes inside the cell and energy generating reactions, as well as rare metabolic conversions. This volume also explores balances and reaction models, the regulation of metabolic pathways, and genome scale and multiscale modeling tools. It also covers developing appropriate hosts for metabolic engineering including the use of Escherichia coli, yeast, Bacillus Subtilis, Streptomyces, filamentous fungi, and mammalian cells using cell culture. Christine Smolke, who recently developed a novel way to churn out large quantities of drugs from genetically modified brewer’s yeast, is regarded as one of the most brilliant new minds in biomedical engineering. In this handbook, she brings together pioneering scientists from dozens of disciplines to provide a complete record of accomplishment in metabolic pathway engineering. With a wealth of cutting edge research and analysis, this work also serves as an invaluable resource for those seeking to add their own contributions. Organized by topic, this 3000 page reference is available as two volumes that can be purchased individually or as a set. For information on the complete handbook visit Cat No. 3923
 

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Contents

Chapter 1 Solute Transport Processes in the Cell
1-1
Chapter 2 Catabolism and Metabolic Fueling Processes
2-1
The Prerequisites of Life
3-1
Chapter 4 Polymerization of Buliding Blocks to Macromolecules Polyhydroxyalkanoates as an Example
4-1
Chapter 5 Rare Metabolic ConversionsHarvesting Diversity through Nature
5-1
Balances and Reaction Models
5-27
Chapter 6 Growth Nutrients and Diversity
6-1
Chapter 7 Mass Balances Rates and Experiments
7-1
Chapter 15 Metabolic Flux Analysis
15-1
Chapter 16 Metabolic Control Analysis
16-1
Chapter 17 Structure and Flux Analysis of Metabolic Networks
17-1
Chapter 18 ConstraintBased GenomeScale Models of Cellular Metabolism
18-1
Chapter 19 Multiscale Modeling of Metabolic Regulation
19-1
Chapter 20 Validation of Metabolic Models
20-1
Developing Appropriate Hosts for Metabolic Engineering
V-1
Chapter 21 Escherichia coli as a WellDeveloped Host for Meabolic Engineering
21-1

Chapter 8 Data Reconciliation and Error Detection
8-1
Chapter 9 Black Box Models for Growth and Product Formation
9-1
Chapter 10 Metabolic Models for Growth and Product Formation
10-1
Chapter 11 A Thermodynamic Description of Microbial Growth and Product Formation
11-1
Bacterial Transcriptional Regulation of Metabolism
11-21
Lessons from a Feral Promoter
12-1
Chapter 13 Regulation of Secondary Metabolism in Bacteria
13-1
Chapter 14 A Synthetic Approach to Transcriptional Regulatory Engineering
14-1
Chpater IV Modeling Tools for Metabolic Engineering
14-17
Chapter 22 Metabolic Engineering in Yeast
22-1
Chapter 23 Metabolic Engineering of Bacillus subtilis
23-1
Chapter 24 Metabolic Engineering of Streptomyces
24-1
Chapter 25 Metabolic Engineering of Filamentous Fungi
25-1
Chapter 26 Metabolic Engineering of Mammalian Cells
26-1
Index
I-1
Back cover
I-15
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