The Natural killer cell
IRL Press at Oxford University Press, 1992 - Health & Fitness - 248 pages
The ability of an organism to combat infection by foreign particles and microbial pathogens is essential for its survival and evolutionary success. Such efforts at immunity can take two forms. A considerable number of works have been published which focus on the central role of antigen recognition and antibody structure and function in the host response to infection. This volume, however, discusses the recent shift in focus towards the "natural" or "innate" immune system which consists of various cell types and factors. These cells and factors can take part in immune responses without prior sensitization, and have important modulatory effects on later, specific responses. This work reviews the biology and function of the natural killer cell, covering such topics as the molecular basis of natural killer cell function and its role in viral infection, tumor biology, and transplantation. Graduate students and researchers in immunology, cell biology, and medicine will find this work a valuable resource on current research in this exciting field.
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Origin differentiation and distribution
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activated killer activity of NK ADCC allogeneic antibacterial activity antibodies antigen assays bacterial Cancer CD8+ cell lines cell populations cell types cell-mediated cytotoxicity clones cytokines cytolytic cytotoxic activity decidual cells decidual LGLs donor effector cells effects of NK enhanced expression gene growth GVHD haematopoietic Herberman herpes simplex virus human natural killer human NK cells IFN-y immune Immunol induced infection inhibit inhibitory interferon interleukin killer cell activity killing kinase LAK activity LAK cells large granular lymphocytes LCMV LGLs lymphoid lymphokine lyse lysis macrophages MCMV mechanisms mediated mice molecules monocytes mouse munol murine natural killer cells necrosis factor NK activity NK cell activity NK cells Ortaldo patients peripheral blood phenotype pregnancy production progenitor cells proliferation protein purified receptor regulation rejection role of NK spleen stem cells stimulation studies suppress suppressor T-cells target cells tion tissue TNFa Trinchieri trophoblast tumour tumour cells tyrosine viral virus virus-infected vitro vivo