The Neuropharmacological Basis of RewardJeffrey M. Liebman, Steven J. Cooper This is the first comprehensive volume devoted to recent studies of the biological basis of reinforcement. The contributors, all prominent physiological psychologists or behavioral pharmacologists, have extensively analysed current research on drugs, brain neurotransmitters, and reinforcement in animals. They present convergent evidence that implicates the nucleus accumbens and its dopaminergic afferents in reward. Controversial themes include the identity of the neurons mediating intracranial self-stimulation, the site(s) where opiate drugs modulate dopamine-mediated effects on reinforcement, and whether or not non-dopaminergic neurons can independently mediate reinforcement. Exciting new technical advances, such as conditioned place preferences, intracranial microinjection, and self-administration of drugs, and new techniques for measuring the specificity of drug effects on reinforcement, are thoroughly explained. Future research directions are outlined. |
Contents
Contributors ix | 1 |
M | 6 |
Pharmacological basis of intracranial selfstimulation reward | 14 |
Copyright | |
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6-OHDA lesions activity agonists amphetamine animals antagonists Bielajew Biochemistry and Behavior Bozarth Brain Research brain stimulation brain-stimulation reward C-T interval cells cocaine codeine collision curve-shift decrease dopamine dopaminergic dorsal dose dose-effect curve electrodes electrophysiological extinction Fibiger fixed-ratio frontal cortex function Gallistel Goeders haloperidol heroin ICSA increase injection intracranial self-stimulation intravenous Journal of Comparative Journal of Pharmacology Koob lateral hypothalamic Liebman maintained responding medial forebrain bundle medial prefrontal cortex method mg/kg Miliaressis morphine naloxone naltrexone neural neuroleptics neurons Neuroscience noradrenergic nucleus accumbens obtained opiate opioid paradigm pathways Pharmacology Phillips Physiology and Behavior pimozide produced psychomotor stimulants Psychopharmacology psychophysical rates of responding rats receptor refractory period region reinforcing effects responding maintained response rates reward fibres reward neurons rewarding effect rhesus monkeys Rompré schedules self-stimulation self-stimulation behaviour Shizgal Spyraki Stellar stimulation reward studies substantia nigra substrates suggest T-pulse ventral tegmental area Wise