The Progress of Experiment: Science and Therapeutic Reform in the United States, 1900-1990

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Cambridge University Press, Oct 2, 2000 - Medical - 258 pages
This book explores the origins of our contemporary system of drug regulation and the modern clinical trial. Marks illustrates the symbiotic relationship between the history of modern drug regulation and the history of therapeutic reform. Accompanying this history of public policy is a detailed account of changing experimental ideals and practices. Marks traces the history of therapeutic experimentation, from the "collective investigations" of the past century to the controlled clinical trial that emerged after 1950 as the paradigm of scientific experimentation. The result is the first general history of clinical research in the United States, a book that examines therapeutic experiments in a wide range of diseases, from syphilis and pneumonia to heart disease and diabetes.
 

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Contents

A rational therapeutics
17
Memories of underdevelopment Therapeutic research in the United States 19001935
42
Playing it safe The Federal Food Drug and Cosmetic Act of 1938
71
War and peace
98
Of methods and institutions or The triumph of statistics
129
Managing chance Statistics and therapeutic experiments 19501960
136
You gotta have heart
164
Anatomy of a controversy The University Group Diabetes Program study
197
The dreams of reason Retrospect and prospect
229
A NOTE ON SOURCES
249
INDEX
251
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