The Telomerase Revolution: The Enzyme That Holds the Key to Human Aging . . . and Will Soon Lead to Longer, Healthier LivesOne of Wall Street Journal's "Best Books for Science Lovers" in 2015 Science is on the cusp of a revolutionary breakthrough. We now understand more about aging—and how to prevent and reverse it—than ever before. In recent years, our understanding of the nature of aging has grown exponentially, and dramatic life extension—even age reversal—has moved from science fiction to real possibility. Dr. Michael Fossel has been in the forefront of aging research for decades and is the author of the definitive textbook on human aging. In The Telomerase Revolution, he takes us on a detailed but highly accessible scientific journey, providing startling insights into the nature of human aging. Twenty years ago, there was still considerable debate of the nature of human aging, with a variety of competing theories in play. But scientific consensus is forming around the telomere theory of aging. The essence of this theory is that human aging is the result of cellular aging. Every time a cell reproduces, its telomeres (the tips of the chromosomes) shorten. With every shortening of the telomeres, the cell's ability to repair its molecules decreases. It ages. Human aging is the result of the aging of the body's trillions of cells. But some of our cells don't age. Sex cells and stem cells can reproduce indefinitely, without aging, because they create telomerase. Telomerase re-lengthens the telomeres, keeping these cells young. The Telomerase Revolution describes how telomerase will soon be used as a powerful therapeutic tool, with the potential to dramatically extend life spans and even reverse human aging. Telomerase-based treatments are already available, and have shown early promise, but much more potent treatments will become available over the next decade. The Telomerase Revolution is the definitive work on the latest science on human aging, covering both the theory and the clinical implications. It takes the reader to the forefront of the upcoming revolution in human medicine. |
Other editions - View all
The Telomerase Revolution: The Enzyme That Holds the Key to Human Aging ... Michael Fossel No preview available - 2017 |
The Telomerase Revolution: The Enzyme That Holds the Key to Human Aging ... Michael Fossel No preview available - 2015 |
The Telomerase Revolution: The Enzyme That Holds the Key to Human Ageing ... Michael Fossel No preview available - 2016 |
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ability actually age-related diseases aging cells aging process Alzheimer’s dementia Alzheimer’s disease atherosclerosis begin beta-amyloid blood pressure body bone brain cancer cells cause cell aging cell division cellular cholesterol chondrocytes chromosomes clinical costs cure damage decrease diet dietary divide effective elderly endothelial cells example exercise free radicals free-radical free-radical theory function gene expression genetic Geron gradual Hayflick Limit healthy heart attack hormone human disease immune system increase infection intervention joint less levels lifespan live loss meditation metabolic microglial cells mitochondria molecules neurons normal occurs organisms osteoarthritis osteoporosis pathology patients pattern of gene percent potential prevent problem progeria pulmonary re-lengthening receptors recycling repair replacement reset response result reverse aging Reversing Human Aging risk factors senescence shortening telomeres skin slow specific stem cells strokes TA Sciences tau proteins telomerase activators telomerase therapy telomere length telomere shortening telomere theory theory of aging tissue understanding vitamins young cells