The Theoretical Foundation of Dendritic Function: Selected Papers of Wilfrid Rall with Commentaries
Wilfrid Rall was a pioneer in establishing the integrative functions of neuronal dendrites that have provided a foundation for neurobiology in general and computational neuroscience in particular. This collection of fifteen previously published papers, some of them not widely available, have been carefully chosen and annotated by Rall's colleagues and other leading neuroscientists. It brings together Rall's work over more than forty years, including his first papers extending cable theory to complex dendritic trees, his ground-breaking paper introducing compartmental analysis to computational neuroscience, and his studies of synaptic integration in motoneurons, dendrodendritic interactions, plasticity of dendritic spines, and active dendritic properties.
Today it is well known that the brain's synaptic information is processed mostly in the dendrites where many of the plastic changes underlying learning and memory take place. It is particularly timely to look again at the work of a major creator of the field, to appreciate where things started and where they have led, and to correct any misinterpretations of Rall's work. The editors' introduction highlights the major insights that were gained from Rall's studies as well as from those of his collaborators and followers. It asks the questions that Rall proposed during his scientific career and briefly summarizes the answers.
The papers include commentaries by Milton Brightman, Robert E. Burke, William R. Holmes, Donald R. Humphrey, Julian J. B. Jack, John Miller, Stephen Redman, John Rinzel, Idan Segev, Gordon M. Shepherd, and Charles Wilson.
What people are saying - Write a review
We haven't found any reviews in the usual places.
Dendritic Function by Idan Segev John Rinzel and Gordon M
Time Constant of Motoneurons
COMPARTMENTAL METHOD FOR MODELING
Synaptic Pathway for Inhibition in the Olfactory Bulb
MOTONEURON MODELS OF DISTRIBUTED
Neuron Model for Current Injected at One Branch
and Velocity for Changing Core Conductor Geometry
Membrane in Dendritic Spines
Editorial Comment with an Excerpt from Rall 1990
Other editions - View all
action potential active amplitude applied assumed assumption attenuation axon boundary branch changes combined compartment computed condition conductance constant corresponding course curve cylinder decay defined dendritic trees depends depolarization diameter discussed distance distribution Eccles effect electrical electrotonic EPSP equal equation equivalent estimate example excitation excitatory experimental expressed extracellular factor figure flow function given granule cell illustrated implies important increase inhibition input resistance larger lateral layer length mathematical means membrane method mitral cell motoneurons neuron neuron model noted obtained olfactory bulb origin parameters particular passive peak period Physiol possible potential present problem propagation properties Rall range ratio recorded reference relation relative represents response shape shown shows significant single slope smaller solution soma spine spread steady stem step surface synaptic input Table terminal theoretical theory tion transient trunk voltage