The Theoretical Foundation of Dendritic Function: Selected Papers of Wilfrid Rall with Commentaries

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MIT Press, 1995 - Medical - 456 pages
Wilfrid Rall was a pioneer in establishing the integrative functions of neuronal dendrites that have provided a foundation for neurobiology in general and computational neuroscience in particular. This collection of fifteen previously published papers, some of them not widely available, have been carefully chosen and annotated by Rall's colleagues and other leading neuroscientists. It brings together Rall's work over more than forty years, including his first papers extending cable theory to complex dendritic trees, his ground-breaking paper introducing compartmental analysis to computational neuroscience, and his studies of synaptic integration in motoneurons, dendrodendritic interactions, plasticity of dendritic spines, and active dendritic properties.

Today it is well known that the brain's synaptic information is processed mostly in the dendrites where many of the plastic changes underlying learning and memory take place. It is particularly timely to look again at the work of a major creator of the field, to appreciate where things started and where they have led, and to correct any misinterpretations of Rall's work. The editors' introduction highlights the major insights that were gained from Rall's studies as well as from those of his collaborators and followers. It asks the questions that Rall proposed during his scientific career and briefly summarizes the answers.

The papers include commentaries by Milton Brightman, Robert E. Burke, William R. Holmes, Donald R. Humphrey, Julian J. B. Jack, John Miller, Stephen Redman, John Rinzel, Idan Segev, Gordon M. Shepherd, and Charles Wilson.
 

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Contents

Dendritic Function by Idan Segev John Rinzel and Gordon M
3
Membrane Resistivity
37
Time Constant of Motoneurons
74
COMPARTMENTAL METHOD FOR MODELING
115
Synaptic Pathway for Inhibition in the Olfactory Bulb
160
MOTONEURON MODELS OF DISTRIBUTED
205
Neuron Model for Current Injected at One Branch
328
and Velocity for Changing Core Conductor Geometry
368
Membrane in Dendritic Spines
420
Editorial Comment with an Excerpt from Rall 1990
441
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