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02 consumption 02 uptake 4-hydroxyphenylarsenious 4-hydroxyphenylarsenious oxide according acid action of SH added at beginning addition amount arsenic arsenious oxides arsenoxide+N/100 SH beginning of experiment catalytic cells cent chemical clearly compounds concentrations CONCLUSIONS considerable consumption of tissues containing converted crystalline crystalline SH glutathione decrease derivative described effect Ehrlich evidence exert fact Figure further glucose glutathione added 15 hydroxylamine I=testis illustrate important increase indicates ineffective influence involved iron Jensen Johnson kidney less liver living Locke solution marked means mechanism ment method MICHIGAN minutes after arsenoxide Mohr's salt moles N/100 SH glutathione negative neoarsphenamine normal tissues observations obtained overcome oxygen consumption possible prepared presence produced pure rate of 02 ratio rats reaction reduction in 02 respect sarcoma SH glutathione added showed shown slightly Smith substance sulpharsphenamine testis in Locke tion toxic tryparsamide utilization vessels Voegtlin Warburg yeast
Page 1 - The influence of arsenicals and crystalline glutathione on the oxygen consumption of tissues.
Page 14 - O2 consumption ues which has been greatly reduced by arsenoxide can be restored to normal by the addition of SH glutathione is the first evidence that glutathione can influence the O2 consumption of living tissues.
Page 1 - United States Public Health Service. The purpose of this paper is to...
Page 2 - The vessels were provided with a side arm, which permitted the addition of the solution of chemicals to the tissue during the course of the experiments.