The Living Brain and Alzheimer's Disease

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B. T. Hyman, Jean-Franc̦ois Demonet, Yves Christen
Springer, Jan 1, 2004 - Medical - 180 pages
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From large cross-sectional studies of autopsy material, it seems as if a time course of Alzheimer's Disease, at least on average, can be mapped out: a pattern of hierarchical vulnerability for neuronal loss and neurofibrillary tangles beginning in medial temporal lobe structures proceeding through association areas. Plaques follow their own temporal course, with widespread cortical deposits occurring even early in a disease process. The whole process may well take twenty years, the first half of which may be without overt symptoms.

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Neuropathology of Alzheimers disease as Seen in Fixed Tissues
Cerebrospinal Fluid Biomarkers for the Diagnosis of Alzheimers Disease
In Vivo Imaging of Alzheimer Pathology

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About the author (2004)

Yves Christen is one of Europe's most prolific science writers. Trained at the Pasteur Institute in Paris, France, he holds his doctorate in immunogenetics, and master's degrees in psychology, biochemistry, and animal biology. The author or co-author of ten books, he has edited nine others. He is currently science editor of "Le Figaro Magazine.

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