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abnormal acne activity Adachi amino acids appear Arch atopic dermatitis atopy biochemical biochemistry Biol biological Biophys cells changes chapter characteristic chemical chondroitin sulphate clinical cofactors collagen complex compounds Cotton D.W.K. cutaneous cyclic AMP deficiency dehydrogenase demonstrated dermatan sulphate Dermatol dermis disease disorders effects enzymatic enzyme epidermis fatty acids figure function genetic glucose glucose-6-phosphate glycogen glycolytic glycosaminoglycans hair follicles Halprin hormones human skin hyaluronic acid increased inflammation inhibition inhibitors Invest investigated irradiation isoenzymes isolated keratin keratinisation Krebs cycle lactate layer lesions lipids lysosomal mammalian mechanism melanin melanocytes membrane metabolism Mier P.D. molecular molecule Montagna mucopolysaccharides normal nucleic acids observation Ohkawara oxidation pathway patients pattern phosphate pigment polysaccharides porphyrias processes produce protein psoriasis psoriatic pyruvate quantitative rat skin reaction reported response role sebaceous glands serum specific structure studied substrate sweat glands synthesis tyrosinase various vitamin vitro workers