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Basic Mechanisms and Environmental MutagenesisA Look Ahead
ZForming DNA Sequences Are Deletion HotSpots
Site Specific Mutagenesis
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4-aminobiphenyl Acad Sci USA activity agents alkylating analysis antibodies AP endonuclease assay bacteria base pairs binding BP-N caffeine Cancer Carcinogenesis carcinogens cDNA cell lines cellular chemical chromosome clones deletions Demple detected dhfr DNA adducts DNA damage DNA ligase DNA polymerase DNA repair DNA replication DNA sequence dose endonuclease enzyme Escherichia coli eukaryotic excision repair exon fibroblasts Figure frameshift function gene genome hamster homologous human cells induced insertion irradiation lambda lesions levels liver locus mammalian cells mechanism methylation mice mismatch repair molecular mouse mutagenesis mutagenic mutation frequency Mutation Res Natl Acad Sci nuclear matrix Nucleic Acids nucleotide oxidative phage photolyase photoreactivation plasmid Proc Natl Acad protein psoralen pyrimidine dimers radiation reaction RecA RecA protein recombination shuttle vector specific strains strand exchange structure studies substrate Table template testing tissues transcription transfection transgenic tumor UmuD UV-induced UvrA vitro vivo xeroderma pigmentosum xrs-5 cells yeast