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DNA binding and polycyclic hydrocarbon carcinogenesis
Biological activity of polycyclic hydrocarbon metabolites and the
Stereoselective metabolic activation of polycyclic aromatic hydrocarbons
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acetaminophen action adducts agents alkylating animals antiandrogens applied aromatic bay region behavioral behavioral toxicology benzo[a]pyrene Biochem biological BP 7,8-dihydrodiol Cancer Res carbon carcinogenesis carcinogenic cells cellular chemical carcinogens chemically reactive metabolites chronic chrysene compounds concentration Conney correlation covalent binding cytochrome D. M. Jerina decrease derivatives Derm dihydrodiols dimethylnitrosamine diol diol-epoxides dose drug E. C. Miller effect electrophilic enantiomer enzyme epidermis epoxide exposure formation formed function glutathione hair growth haloalkanes hamster hepatic horny layer human increase induced inhibition interaction isoenzyme Levin lipid liver liver microsomes mechanisms metabolic activation metabolites methyl mice microsomal mouse skin mutagenic N-hydroxyacetaminophen neurotoxins nitrosamine nucleic acids oxidation pathway Pharmacol Pharmacology phenacetin polycyclic hydrocarbons potential Proc prostaglandin protein rat liver reaction Salmonella sebaceous glands specific studies substances sweat Thakker tissue topical application toxic toxicology toxin treatment tumorigenic tumors ultimate carcinogenic vinyl chloride vitro vivo Yagi