Treatment of Primary Glomerulonephritis
Claudio Ponticelli, Richard J. Glassock
Oxford University Press, 2009 - Medical - 481 pages
Primary glomerulonephritis is a common renal disease which may eventually lead to chronic renal failure. Treatment of glomerulonephritis is difficult. In particular, the use of glucocorticoids and immunosuppressive drugs require expertise, knowledge of the drugs, and careful monitoring of the patient. Paradoxically, the treatment of glomerulonephritis has become even more complicated in the recent years, after the introduction of a number of newer immunosuppressive drugs.
Extensively updated since publication of the first edition in 1997, this comprehensive yet concise guide to the treatment of even the most complex patients with primary glomerular diseases is full of practical information collected and organized in an easy-to-read manner. It encompasses the possible treatments of the different types of primary glomerulonephritis, including diseases intrinsic to the kidney of unknown or uncertain aetiology. Each of the main chapters is devoted to a single primary glomerulonephritis and follows a similar format to allow easy access of information.
The book contains not only an evidence-based review of the topic, but also practical recommendations from internationally recognized experts in the field.
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1 Symptomatic therapy
2 Glucocorticoids and immunomodulating agents
3 Evaluation of observational and controlled trials of therapy
4 Acute postinfectious glomerulonephritis
5 Minimal change nephropathy
6 Focal and segmental glomerular sclerosis
7 Membranous nephropathy
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abnormal ACEi activity acute adults agents albumin ANCA and/or anti-GBM antibody antigen associated azathioprine biopsy capillary Cattran cells chlorambucil chronic Clin clinical complete remission controlled trials crescentic CrGN cyclophosphamide cyclosporine cytotoxic deposits develop diagnosis diuretics dosage dose drug edema ESRD excretion factors focal segmental glomerulosclerosis follow-up FSGS Glassock glomeruli glomerulonephritis glucocorticoids hematuria hypertension idiopathic IgA nephropathy immune immunosuppressive increased infection inhibit inhibitors intravenous Kidney Diseases Kidney International leflunomide lesions levels long-term membranoproliferative membranous nephropathy mesangial methylprednisolone microscopy minimal change mizoribine months MPGN mycophenolate nephritis Nephrology nephrotic syndrome oral outcome partial remission pathogenesis patients with IgA plasma plasmapheresis podocyte Ponticelli prednisone prognosis progression protein proteinuria receptor recurrence reduce regimen relapses renal biopsy renal disease renal failure renal function reported response risk rituximab segmental glomerulosclerosis serum creatinine side effects steroid-resistant steroids studies tacrolimus therapy tion toxicity treated treatment vasculitis