Tremor: From Pathogenesis to Treatment

Front Cover
Morgan & Claypool Publishers, 2008 - Technology & Engineering - 211 pages
0 Reviews
Tremor represents one of the most common movement disorders worldwide. It affects both sexes and may occur at any age. In most cases, tremor is disabling and causes social difficulties, resulting in poorer quality of life. Tremor is now recognized as a public health issue given the aging of the population. Tremor is a complex phenomenon that has attracted the attention of scientists from various disciplines. Tremor results from dynamic interactions between multiple synaptically coupled neuronal systems and the biomechanical, physical, and electrical properties of the external effectors. There have been major advances in our understanding of tremor pathogenesis these last three decades, thanks to new imaging techniques and genetic discoveries. Moreover, significant progress in computer technologies, developments of reliable and unobtrusive wearable sensors, improvements in miniaturization, and advances in signal processing have opened new perspectives for the accurate characterization and daily monitoring of tremor. New therapies are emerging. In this book, we provide an overview of tremor from pathogenesis to therapeutic aspects. We review the definitions, the classification of the varieties of tremor, and the contribution of central versus peripheral mechanisms. Neuroanatomical, neurophysiological, neurochemical, and pharmacological topics related to tremor are pointed out. Our goals are to explain the fundamental basis of tremor generation, to show the recent technological developments, especially in instrumentation, which are reshaping research and clinical practice, and to provide up-to-date information related to emerging therapies. The integrative transdisciplinary approach has been used, combining engineering and physiological principles to diagnose, monitor, and treat tremor. Guidelines for evaluation of tremor are explained.
 

What people are saying - Write a review

We haven't found any reviews in the usual places.

Selected pages

Contents

612 Clinical Scales
84
6121 Evaluation of Drawings
86
6122 Correlation of Postural Tremor with Quantified Tests
87
62 Electromyography and Motor Unit Studies
88
63 Kinmatic Studies
90
631 Accelerometry
93
632 Gyroscopes
94
633 Electromagnetic Tracking Systems
95

232 Cerebellar Nuclei
16
234 Mossy Fibers
17
236 Projections of Cerebellar Nuclei
18
241 Organization of Motoneurons
22
26 Neuromuscular Junction
23
271 Recruitment of Motoneurons
25
References
26
Physiology of the Nervous System
29
32 The Synapses
31
Neurotransmitters and their Receptors
34
332 GammaAminobutyric Acid and Glycine
35
35 Structures Involved in Information Processing and Movement Control
36
354 Cerebellum and Inferior Olivary Complex
37
358 Posterior Parietal Cortex
38
Characterization of Tremor
39
41 Physiological Tremor and Enhanced Physiological Tremor
40
42 Rest Tremor
42
44 Kinetic Tremor
43
45 Action Tremor
47
462 TaskSpecific Tremor
48
465 Cortical Tremor
49
467 Palatal Tremor
50
468 Tremor After a Peripheral Nerve Injury
51
Principal Disorders Associated with Tremor
55
52 Idiopathic Parkinsons Disease
58
522 Nonmotor Tests
59
524 Differential Diagnosis
61
525 Neuroimaging
62
53 Cerebellar Diseases
63
531 Cerebellar Syndrome Induced by Drugs or Toxic Agents
65
542 Jaw Tremor
66
546 Orthostatic Tremor
67
547 Primary Writing Tremor
68
549 FragileXAssociated TremorAtaxia Syndrome
69
5412 Tremor in Postinfectious Syndromes
70
5414 Alcohol Abuse and Alcohol Withdrawal Syndrome
71
55 Role of Brain Imaging in the Differential Diagnosis of Tremor
72
553 Transcranial Sonography
73
Quantification of Tremor
81
61 Clinical Examination and Clinical Scales
82
635 Videos
96
636 Optoelectronic Devices
97
65 Signal Processing
99
652 Fourier Transforms
100
653 Drawbacks of FFT Analysis
102
655 Wavelets
103
656 Fuzzy Logic
104
657 CrossSpectral Analysis and Coherence
105
References
106
Mechanisms of Tremor
109
722 Positron Emission Tomography
111
75 Enhanced Physiological Tremor
115
77 Rest Tremor Parkinsons Disease
119
78 Kinetic Tremor
122
79 Orthostatic Tremor
123
710 Other Tremors
124
7104 Primary Writing Tremor
125
7107 Cortical Tremor
126
References
128
Treatments
137
811 Ethanol
139
812 Primidone
148
815 Antiepileptic Drugs
149
817 Other Drugs
150
82 Deep Brain Stimulation and Surgical Treatments
151
823 Complications of DBS
153
824 Lesion of the Vim
154
827 Stimulation Versus Lesion?
155
831 Complications
156
86 BrainMachine Interfaces
158
88 Fuzzy Logics
159
References
160
ANNEX 1
167
ANNEX 2
171
ANNEX 3
175
List of Abbreviations
185
Author Biography
191
Index
193
Copyright

Other editions - View all

Common terms and phrases

Bibliographic information