Understanding DNA: The Molecule and How it Works

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Academic Press, Mar 13, 2004 - Science - 352 pages
3 Reviews

The functional properties of any molecule are directly related to, and affected by, its structure. This is especially true for DNA, the molecular that carries the code for all life on earth.

The third edition of Understanding DNA has been entirely revised and updated, and expanded to cover new advances in our understanding. It explains, step by step, how DNA forms specific structures, the nature of these structures and how they fundamentally affect the biological processes of transcription and replication.

Written in a clear, concise and lively fashion, Understanding DNA is essential reading for all molecular biology, biochemistry and genetics students, to newcomers to the field from other areas such as chemistry or physics, and even for seasoned researchers, who really want to understand DNA.

  • Describes the basic units of DNA and how these form the double helix, and the various types of DNA double helix
  • Outlines the methods used to study DNA structure
  • Contains over 130 illustrations, some in full color, as well as exercises and further readings to stimulate student comprehension

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LibraryThing Review

User Review  - name99 - LibraryThing

A book that is very definitely biochemistry rather than molecular biology. None of that stuff about genes, expression, operons and so on. This was about the physical properties of the DNA molecule ... Read full review


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Popular passages

Page 12 - Isoleucine; Leu, Leucine; Lys, Lysine; Met, Methionine; Phe, Phenylalanine; Pro, Proline; Ser, Serine; Thr, Threonine; Trp, Tryptophan; Tyr, Tyrosine; Val, Valine.
Page xi - Almost all aspects of life are engineered at the molecular level, and without understanding molecules we can only have a very sketchy understanding of life itself.
Page 322 - Yokota, T., Sakamoto, N., Enomoto, N., Tanabe, Y, Miyagishi, M., Maekawa, S., Yi, L., Kurosaki, M., Taira, K., Watanabe, M. and Mizusawa, H. 2003. Inhibition of intracellular hepatitis C virus replication by synthetic and vector-derived small interfering RNAs. EMBO Rep.
Page 320 - Scott, WG, Finch, JT and Klug, A. (1995). The crystal structure of an all-RNA hammerhead ribozyme : A proposed mechanism for RNA catalytic cleavage.
Page 320 - Haseloff, J and Gerlach, WL (1988) Simple RNA enzymes with new and highly specific endoribonuclease activities Nature 334, 585-591 6 Ruffner, D E., Stormo, G D., and Uhlenbeck, O C.

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About the author (2004)

Chris Calladine is Professor of Structural Mechanics at the University of Cambridge. In addition to researching aspects of structural engineering, he has applied the methods of structural mechanics to the study of flagella and DNA.

Horace Drew solved several of the first DNA crystal X-ray structures with Richard Dickerson at Caltech, and subsequently spent five years researching DNA and chromosome structures with Aaron Klug at the MRC Laboratory of Molecular Biology in Cambridge, UK He now lives in Australia and is a Principle Research Scientist at the CSIRO Division of Biomolecular Engineering in Sydney.

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