Uric Acid

Front Cover
William N. Kelley, Irwin M. Weiner
Springer-Verlag, Jan 1, 1978 - Gout - 639 pages
Uric acid has attracted the attention of scientists from a broad spectrum of disciplines, and in recent years dramatic progress has occurred within many of these disciplines. This volume is designed to fill void in the field. Major works in the past five years have provided comprehensive reviews of disorders of uric acid metabolism for the clinical (1-3) as well as short reports of recent progress for the interested scholar (4, 5). In Uric Acid the reader will find extensive reviews of relevant topics selected largely by virtue of recent progress in the field and written by those who, to a considerable extent, qre responsible for that progress. Seven chapters are dedicated to a description of uric acid synthesis, its control, diseases resulting from aberrations in the pathway, and effects of intermediates and end products of this pathway on other metabolic processes. The next five chapters describe our current understanding of the mechanisms by which uric acid is elimi­ nated by the organism. Then seven chapters review the factors responsible for the human "disease" produced by uric acid in the joints and kidneys. The final four chapters provide a summary of therapeutic approaches to control gout, the most important disease caused per se by uric acid.

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Contents

Production
1
References
16
CHAPTER 3
26
References
38
Purine Salvage Enzymes W J ARNOLD
43
E Clinical Syndromes Associated with a Deficiency of APRT
64
CHAPTER 4
75
Functions of the Reactions of Purine Nucleotide Interconversion
84
F Conclusion
334
Conclusion
344
Speculations on Altered Connective Tissue Metabolism in Gout
355
G Conclusion
362
CHAPTER 15
365
Termination of the Acute Gouty Attack
373
CHAPTER 16
379
Cavitation
385

CHAPTER 5
93
Regulation of Purine Nucleotide Degradation
108
F Relationship of Purine Nucleotide Degradation to Immune Function
114
CHAPTER 6
125
E Disorders in Nucleotide Biosynthesis Induced by Exogenous Purines
133
F Role of Cellular Levels of Phosphoribosyl Pyrophosphate in Coordinate
140
References
148
CHAPTER 7
155
Studies of PRPP Metabolism in Uric Acid Overproducers Without
167
E PRPP Metabolism in Enzyme Defects Associated with Uric Acid Over
169
References
178
Renal Disposal
185
Chemical Forms of Urates in Urine
200
E Concluding Remarks
206
B Methods of Investigation
212
References
247
CHAPTER 10
257
Plasma Urate and GFR
263
Urate Excretion in Gout
274
References
280
CHAPTER 11
287
Drugs Affecting Urate Excretion
296
References
315
Extrarenal Disposal
325
H Crystal Deposits
391
Nephrolithiasis and Urate Nephropathy
397
J Management of Uric Acid Nephrolithiasis
413
CHAPTER 18
423
E UrateOxalate Epitaxis
429
F Reduced Urine Inhibitors
436
CHAPTER 19
443
E Structural Alterations in the Gouty Kidney
447
F Miscellaneous Observations
454
Drug Metabolism
462
F Clinically Important Uricosuric Drugs
468
References
479
CHAPTER 21
485
Inhibition of Xanthine Oxidase In Vivo
487
F Effects on Purine Biosynthesis
496
K Other Xanthine Oxidase Inhibitors
504
CHAPTER 22
515
Limits Indicators Methods
523
CHAPTER 23
525
Phenylbutazone and Oxyphenbutazone
540
E Naproxen
546
Author Index
557
Subject Index
619
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