Use of Estrogen and Rehabilitation to Improve Recovery in the Collagenase Model of Intracerebral Hemorrhage in Rats

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Library & Archives Canada, 2008 - Brain - 1008 pages
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The second portion of my thesis concerns the behavioural deficits associated with ICH. Intensive rehabilitation improves functional outcome after ICH in rats. Environmental enrichment (EE) promotes recovery in several other stroke models. Estrogen treatment prior to ICH has also been shown to be neuroprotective. We hypothesized that either estrogen and/or EE might modify the natural history of ongoing injury following ICH when applied in the late period. Moreover, we questioned whether estrogen and EE might act synergistically when given together. I therefore examined the effect of both interventions on functional and histologic measures of ICH in rats. Briefly, I found that EE can promote recovery after ICH injury; however, estrogen treatment does not add to his effect. The possible interpretations of these results and future directions are discussed.

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