Uses of Inorganic Chemistry in Medicine
Royal Society of Chemistry, Jan 1, 1999 - Medical - 159 pages
Metal-based drugs are a commercially important sector of the pharmaceutical business, yet most bioinorganic textbooks lack the space to cover comprehensively the subject of metals in medicine. Uses of Inorganic Chemistry in Medicine approaches an understanding of the topic in a didactic and systematic manner. The field of inorganic chemistry in medicine may usefully be divided into two main categories - drugs which target metal ions in some form, whether free or protein-bound, and secondly, metal-based drugs where the central metal ion is usually the key feature of the mechanism of action. This latter category can further be subdivided into pharmacodynamic and chemotherapeutic applications, as well as those of imaging. The book summarises the chemical and biological studies on clinically used agents of lithium, gold and platinum, as well as highlighting the research on prospective new drugs, including those based on vanadium and manganese. The coverage allows a clear distinction between pharmacodynamic and therapeutic properties of metal-based drugs and focuses not only on those clinical agents in current use, but also on new drugs and uses. This book serves to fill an important niche, bridging bioinorganic and medicinal chemistry and will undoubtedly be of use to senior undergraduates and postgraduates, as well as being an invaluable asset for teachers and researchers in the discipline.
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Metal Complexes as Diagnostic Agents
New Uses of Lithium
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Acad acid adducts agents analogues anti-tumour auranofin binding Biochem Biochemistry Biol biological Biophys Bleomycin blood C.F. Shaw Cancer Res carboplatin catalyze cells cellular chelating Chem chemistry chrysotherapy cisplatin Clin compounds concentrations coordination cross-link cysteine cytotoxic D.H. Petering D.P. Riley diabetic dismutation dose DPPE effects enzyme Fe(m)Blm FeBlm Figure formation Gallicchio glucose glutathione gold complexes gold drugs gold(i human inhibition Inorg inorganic insulin interaction interstrand intracellular J.H. McNeill K.R. Harrap kinase kinetic ligand lithium membrane metabolism metal domain metal ions metal-based metalloproteins Mn(n Mn(n)-based SOD mimics molecule N.J. Birch Natl nitrate nitric oxide oral ovarian P.J. Sadler pathway patients peptides peroxynitrite Pharmacol plasma potential Proc production protein rats reaction redox reduced role SOD activity SOD enzyme specific stability structure studies Superoxide Dismutase therapeutic therapy thiolate thiols tissue toxic treatment tumor tyrosine uptake V.S. Gallicchio vanadate vanadium vanadyl vasodilation vitro vivo