Water and Biological Macromolecules

Front Cover
CRC Press, Aug 16, 1993 - Science - 468 pages
Water and Biological Macromolecules presents an excellent description of the structural aspects of water molecules around biological macromolecules. Topics discussed include the properties of water in solid and liquid states; proteins, nucleic acids, polysaccharides, and lipids; and theoretical approaches for understanding the macroscopic observations and integrating microscopic descriptions. The nature and roles of hydration forces in macromolecular complexation and cell-cell interactions are explained, in addition to phenomena such as entropy-enthalpy compensation and the thermodynamic treatment of water bridging.

Water and Biological Macromolecules will be a valuable reference for biophysicists, biochemists, and macromolecular biologists.
 

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Contents

Water structure
3
Thermodynamic and dynamic properties of water
45
Proteins
61
Highresolution
98
Hydration of protein secondary structures the role
148
Molecular dynamics simulations on the hydration structure
165
Structural water bridges in nucleic acids
226
Hydration sites and hydration bridges around DNA helices
244
Hydration force
374
Relevance of lipid hydration
376
Thermodynamics
391
Hydration forces C J van Oss
393
Theory
394
Negative interfacial tensions and polar repulsion
401
Quantitative expression of hydrophilicity and hydrophobicity
403
Hydration orientation
407

Light scattering spectroscopy studies of the water molecules
266
Polysaccharide interactions with water
295
The role of structural water molecules in proteinsaccharide
321
Enzymes
324
Lectins
326
Discussion and Conclusion
334
Lipid hydration G Cevc
338
Sources of lipid hydration
340
Temperature effects
348
Ion and solute effects
349
Modelling lipidwater interactions
351
Consequences of lipid hydration
358
Lipid aggregation in water
373
Consequences and examples of hydration forces
413
Solvation forces in nonaqueous media
419
How specific interactions overcome hydration forces
422
Solvation thermodynamics of biopolymers A BenNaim
430
Definitions
431
The ingredients of AG
436
Some illustrative numerical examples
441
Critique of the group additivity assumption for the solvation Gibbs energy
446
Examples of biochemical processes affected by solvation
450
Solvation and structural changes in the solvent
455
Conclusion
458
Index
461
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Page 381 - Interacting phospholipid bilayers: measured forces and induced structural changes.

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