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Prevalence and genetics
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abnormalities Alzheimer type astrocytes Asymptomatic basal ganglia biliary brain caeruloplasmin concentration chelating agents chronic active hepatitis cirrhosis clinical copper balance copper levels copper toxicosis decoppering decreased dentate nucleus described diagnosis of Wilson's dose drug dry weight dysarthria dystonia dystonic effect excretion of copper Figure free copper concentration fulminant hepatic g dry glial cells grey matter haemolysis hepatic copper hepatic encephalopathy hepatic Wilson's disease hepatocytes hepatolenticular degeneration Hoogenraad increased Journal K-F rings Kayser-Fleischer rings lesions liver biopsy liver copper liver disease liver failure liver transplantation metallothionein neurological manifestations normal patients with neurological patients with Wilson's penicillamine penicillamine therapy plasma copper plasma free copper postural tremor presymptomatic protein protoplasmic astrocytes pseudosclerosis putamen Scheinberg and Sternlieb Schouwink side-effects stain studies syndrome Table tetrathiomolybdate toxic treatment of Wilson's treatment with penicillamine trientine ug per g urinary copper excretion urinary excretion urine Walshe white matter Wilson's disease Wilson's disease gene zinc sulphate