Xenobiotics and Inflammation: Roles of Cytokines and Growth Factors

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Academic Press, Dec 2, 2012 - Medical - 361 pages
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The affect of xenobiotics on host resistance in general and specific immune functions has become the focus of much current research. This book synthesises current information on how chemicals (xenobiotics) can affect the immune system to cuse dysfunction, focusing on the process of inflammation. It provides a much needed, single-source reference for researchers investigation the mechanisms responsible for altered host resistance following exposture to xenobiotics. Emphasis is placed on the roles of cytokines and growth factors in the inflammatory process and how such processes are altered and modulated by xenobiotics. This volume contains information pertinent to those exploring cell growth, angiogenesis, hematopoetic differentiation, and recruitment to and proliferation of cells in various tissue sites. This volume brings together experts in inflammation, cytokines, cell growth, immunology and toxicology to provide a highly yseful volume modulated by chemicals. Divided into three sections, the book offers an organ system approach to understanding inflammation and xenobiotics.
 

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Contents

An Overview
1
Chapter 2 The Inflammatory Process
17
An Overview
33
Cytokines and AcutePhase Proteins
71
Novel Therapeutic Approaches
97
Chapter 6 Bone Marrow Phagocytes Inflammatory Mediators and Benzene Toxicity
149
Induction of Cytokines Affecting Macrophage Differentiation and Functions
173
Chapter 8 Effects of Metals on Lymphocyte Development and Function
193
Chapter 9 XenobioticInduced Skin Toxicity
217
A Cytokine Hypothesis
233
Chapter 11 OzoneInduced Inflammatory Response in Pulmonary Cells
249
Chapter 12 Pulmonary Fibrosis Induced by Silica Asbestos and Bleomycin
283
Chapter 13 Nonparenchymal Cells Inflammatory Mediators and Hepatotoxicity
301
Viral Infection and ImmuneMediated Inflammation
321
Index
349
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