Obesity: Genomics and Postgenomics

Front Cover
Karine Clement, Thorkild I. A. Sorensen
CRC Press, Sep 12, 2007 - Medical - 600 pages
2 Reviews
This book comprehensively accounts the current understanding of genetic mechanisms of obesity by analyzing obesity phenotypes and genotypes and, gene polymorphisms and mutations, and current results from animal model research and genetic studies in human models. By presenting the impact of genetic factors in the development of obesity and key molecules related to the pathophysiology of the disease, this source hopes to pinpoint new pathways for the prevention and management of obesity in various populations.
 

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The book on " obesity :Genomics and post genomics" is an excellent book for reference. The genetic and environmental factors in the development of obesity are clearly explained. It would serve as a excellent study material for all who peruse research in genetics of obesity.

Contents

Obesity Phenotype
1
Quantitative Genetics of Obesity
19
Chapter 22 Adoption Studies
29
Chapter 23 Twin Studies
39
Chapter 24 Experimental Twin Studies
49
Chapter 25 Commingling and Segregation Analyses
59
Rodent Models of Obesity
77
Chapter 32 Transgenic Models Targeting the Central Nervous System
89
Chapter 72 Genetics of Physical Activity
277
Chapter 73 Interaction Between Genes and Lifestyle Factors
287
Chapter 74 Genetics and Hormonal Changes
327
Chapter 75 Genetics and Drugs
337
Epigenetics in Obesity
347
Chapter 82 Implications for Obesity and Common Diseases
365
Tissue and OrganSpecific Gene Function
407
Chapter 92 Genetics of AdiposeTissue Development and Function in Humans
413

Chapter 33 Transgenic Models in the Periphery
109
Chapter 32 Natural Polygenic Models
125
Nonvertebrate Models
143
Syndromic and Monogenic Human Obesity
157
Chapter 52 PraderWilli Syndrome
179
New Insights into Ciliopathies and Oligogenic Traits
195
Chapter 54 Leptin and Leptin Receptor Mutations
205
Chapter 55 POMC and PC1 Mutations
213
Chapter 56 MC4R Mutations
221
Polygenic Human Obesity
229
Chapter 62 GenomeWide Approaches
247
Chapter 63 Association and Linkage Studies in Caucasians
255
GeneEnvironment Interaction in Human Obesity
265
Chapter 93 Nutritional Regulation of Adipocyte Differentiation
429
Chapter 94 Genes Involved in Muscle Function
451
Chapter 95 Genes Involved in Gut and Brain Dialogue
461
Omics Technology and System Biology
473
Chapter 102 Analysis and Data Integration
491
Chapter 103 Transcriptomics Results
513
Chapter 104 Proteomics and Metabonomics Routes Toward Obesity
527
Chapter 105 Quantitative Proteomics for Analysis of Adipocyte Development and Function
537
Conclusion
549
Index
563
Back cover
585
Copyright

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Page 15 - Vague J. The degree of masculine differentiation of obesities: a factor determining predisposition to diabetes, atherosclerosis, gout, and uric calculous disease.
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