UHMWPE Biomaterials Handbook: Ultra High Molecular Weight Polyethylene in Total Joint Replacement and Medical Devices

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Steven M. Kurtz
Academic Press, Apr 27, 2009 - Technology & Engineering - 568 pages

UHMWPE Biomaterials Handbook describes the science, development, properties and application of of ultra-high molecular weight polyethylene (UHMWPE) used in artificial joints. This material is currently used in 1.4 million patients around the world every year for use in the hip, knee, upper extremities, and spine.

Since the publication of the 1st edition there have been major advances in the development and clinical adoption of highly crosslinked UHMWPE for hip and knee replacement. There has also been a major international effort to introduce Vitamin E stabilized UHMWPE for patients. The accumulated knowledge on these two classes of materials are a key feature of the 2nd edition, along with an additional 19 additional chapters providing coverage of the key engineering aspects (biomechanical and materials science) and clinical/biological performance of UHMWPE, providing a more complete reference for industrial and academic materials specialists, and for surgeons and clinicians who require an understanding of the biomaterials properties of UHMWPE to work successfully on patient applications.

  • The UHMWPE Handbook is the comprehensive reference for professionals, researchers, and clinicians working with biomaterials technologies for joint replacement
  • New to this edition: 19 new chapters keep readers up to date with this fast moving topic, including a new section on UHMWPE biomaterials; highly crosslinked UHMWPE for hip and knee replacement; Vitamin E stabilized UHMWPE for patients; clinical performance, tribology an biologic interaction of UHMWPE
  • State-of-the-art coverage of UHMWPE technology, orthopedic applications, biomaterial characterisation and engineering aspects from recognised leaders in the field

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Chapter 20 Compendium of Highly Crosslinked UHMWPEs
Chapter 21 Mechanisms of Crosslinking Oxidative Degradation and Stabilization of UHMWPE
Chapter 22 In Vivo Oxidation of UHMWPE
Chapter 23 Pathophysiologic Reactions to UHMWPE Wear Particles
Chapter 24 Characterization of Physical Chemical and Mechanical Properties of UHMWPE
Chapter 25 Tribological Assessment of UHMWPE in the Hip
Chapter 26 Tribological Assessment of UHMWPE in the Knee
Chapter 27 Characterization of UHMWPE Wear Particles

Chapter 9 The Clinical Performance of UHMWPE in Shoulder Replacements
Chapter 10 The Clinical Performance of UHMWPE in Elbow Replacements
Chapter 11 Applications of UHMWPE in Total Ankle Replacements
Chapter 12 The Clinical Performance of UHMWPE in the Spine
Chapter 13 Highly Crosslinked and Melted UHMWPE
Chapter 14 Highly Crosslinked and Annealed UHMWPE
Chapter 15 Highly Crosslinked UHMWPE Doped with Vitamin E
Chapter 16 VitaminEBlended UHMWPE Biomaterials
Chapter 17 Composite UHMWPE Biomaterials and Fibers
Chapter 18 UHMWPEHyaluronan Microcomposite Biomaterials
Chapter 19 High Pressure Crystallized UHMWPEs
Chapter 28 Clinical Surveillance of UHMWPE Using Radiographic Methods
Chapter 29 ESR Insights into Macroradicals in UHMWPEM
Chapter 30 Fatigue and Fracture of UHMWPE
Chapter 31 Development and Application of the Notched Tensile Test to UHMWPE
Chapter 32 Development and Application of the Small Punch Test to UHMWPE
Chapter 33 Nano and Microindentation Testing of UHMWPE
Chapter 34 MicroCT Analysis of Wear and Damage in UHMWPE
Chapter 35 Computer Modeling and Simulation of UHMWPE

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About the author (2009)

Dr. Kurtz has been researching ultra-high molecular weight polyehtylene(UHMWPE) for use in orthopedics for over 10 years. He has published dozens of papers and several book chapters related to UHMWPE used in joint replacement. He has pioneered the development of new test methods for the material in orthopedics. Dr. Kurtz has authored national and international standards for medical upgrade UHMWPE.

As a principle engineer at Exponent, an international engineering and scientific consulting company, his research on UHMWPE is supported by several major orthopedic manufacturers. He has funding from the National Institutes for Health to stdy UHMWPE changes after implanatation in the body, as well as to develop new computer-based tools to predict the performance of new UHMWPE materials.

Dr. Kurtz is the Director of an orthopedic implant retrieval program in Philadelphia which is affiliated with Drexel University and Thomas Jefferson University. He teaches classes on the performance of orthopedic polymers (including UHMWPE) at Drexel, Temple, and Princeton Universities.

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