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THE RELATIVE IMP0RTANCE 0F Ah VERSUS H2 GEN0TYPE
EFFECTS 0F ACUTE IN VITR0 EXP0SURE
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3-methylcholanthrene 40 mg/kg MC accessory cells adult worms Ah genotype Ah locus Ah receptor AHH activity AHH-inducible alter antibody antigen presentation approximately aryl hydrocarbon hydroxylase assay B6 and D2 B6 strain benzo(a)pyrene C3HeB/FeJ carcinogenesis carcinogenic cellular chemotactic chemotaxis compounds concentration Conney corn oil culture cuvette cytochrome P-450 D2 mice DBA/2 mice dilution DMBA enzyme exposure to MC Figure fluorescence gene genetic genotype Gibco hepatic hepatic microsomal immune responses immune suppression immunotoxicity increase incubation induction Interleukin-1 macrophages MC exposure MC treatment MC-induced immunosuppression MC-treated mice metabolic activation metabolites microsomal mouse muscle larvae antigen Nebert observed PAHCs pasteur pipette peritoneal polycyclic aromatic hydrocarbons proliferation reaction buffer reaction mix resident peritoneal macrophages RPMs sample significant significantly different specific splenic splenocytes stimulated strains of mice substrate superoxide superoxide production T-cell T-cell dependent treated mice Trichinella spiralis ug/ml Vehicle Control vehicle-treated vitro vivo Wassom