Interactive Knowledge Discovery and Data Mining in Biomedical Informatics: State-of-the-Art and Future Challenges

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Andreas Holzinger, Igor Jurisica
Springer, Jun 17, 2014 - Computers - 357 pages
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One of the grand challenges in our digital world are the large, complex and often weakly structured data sets, and massive amounts of unstructured information. This “big data” challenge is most evident in biomedical informatics: the trend towards precision medicine has resulted in an explosion in the amount of generated biomedical data sets. Despite the fact that human experts are very good at pattern recognition in dimensions of = 3; most of the data is high-dimensional, which makes manual analysis often impossible and neither the medical doctor nor the biomedical researcher can memorize all these facts. A synergistic combination of methodologies and approaches of two fields offer ideal conditions towards unraveling these problems: Human–Computer Interaction (HCI) and Knowledge Discovery/Data Mining (KDD), with the goal of supporting human capabilities with machine learning./ppThis state-of-the-art survey is an output of the HCI-KDD expert network and features 19 carefully selected and reviewed papers related to seven hot and promising research areas: Area 1: Data Integration, Data Pre-processing and Data Mapping; Area 2: Data Mining Algorithms; Area 3: Graph-based Data Mining; Area 4: Entropy-Based Data Mining; Area 5: Topological Data Mining; Area 6 Data Visualization and Area 7: Privacy, Data Protection, Safety and Security.

 

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Contents

The Future Is in Integrative Interactive Machine Learning Solutions
1
Effective Exploration of the Biological Universe
19
Darwin or Lamarck? Future Challenges in Evolutionary Algorithms for Knowledge Discovery and Data Mining
34
Step One in the Knowledge Discovery Process
57
Adapted Features and Instance Selection for Improving Cotraining
81
Knowledge Discovery and Visualization of Clusters for Erythromycin Related Adverse Events in the FDA Drug Adverse Event Reporting System
101
On ComputationallyEnhanced Visual Analysis of Heterogeneous Data and Its Application in Biomedical Informatics
117
A PolicyBased Cleansing and Integration Framework for Labour and Healthcare Data
141
On EntropyBased Data Mining
209
Sparse Inverse Covariance Estimation for Graph Representation of Feature Structure
227
StateoftheArt and Future Challenges
241
Bridging Genomics Integrative Biology and Translational Medicine
255
StateoftheArt Open Problems and Future Challenges
271
Protecting Anonymity in DataDriven Biomedical Science
301
Open Problems and Future Challenges
317
On Topological Data Mining
331

Interactive Data Exploration Using Pattern Mining
169
Resources for Studying Statistical Analysis of Biomedical Data and R
183
A KernelBased Framework for Medical BigData Analytics
197

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