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activity AIDS Res Hum amino acid analysis antigen antisense DNA apoptosis assay B-LCL blood mononuclear cells CD4+ T cells cell lines cellular clinical clones correlation culture supernatants cytokine cytotoxic DaunoXome detected dilution dimer disease dose effect ELISA epitopes expression gene glycoprotein HIV Type HIV-1 group HIV-1 RNA HIV-infected individuals human immunodeficiency virus IFN-y immune responses immunodeficiency virus type Immunol incubated induce infection inhibition interleukin intranasal isolates levels lymphocytes M/Ms macrophages metabolic molecular molecules monkeys monoclonal antibodies monocytes mucosal Natl Acad Sci neutralization NF-kB nucleotides patients PBMCs peptide pg/ml phenotype plasma primary primers Proc Natl Acad production protein receptor recombinant region replication Res Hum Retroviruses rhesus macaques samples sequences sera serum simian immunodeficiency virus strains subtype thalidomide therapy tion titers TNF-a treatment urea V3 loop vaccine vaginal viral Virol viruses vitro vivo