Neuromodulation: The Biochemical Control of Neuronal Excitability
This volume provides an introduction to the general principles of neuromodulation--the key neurobiological process for understanding how the brain works. Emphasizing ion channels and biochemical mechanisms of protein phosphorylation, the book shows how neurons regulate their intracellular calcium concentration by modulating the activity of certain ion channels. It goes on to explain the function of intracellular calcium and describes some fascinating neuromodulatory phenomena in the mammalian brain that have long awaited the kind of mechanistic investigations possible in simpler systems. Bridging the gap between neurochemistry and neurophysiology, the authors make complex concepts and research approaches comprehensible to scientists in either field.
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What Is Neuromodulation
How Ion Channel Proteins Work
Biochemical Mechanisms That Regulate the Properties
Phosphorylation of Purified Ion Channel Proteins
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A-current Acad action potential adenylate cyclase amino acid AMP-dependent protein kinase behavior bilayer biochemical Biol brain bullfrog bursting calcium channels calcium current catalytic subunit cell neurons changes channel activity Chapter Chem conductance cyclic AMP cyclic AMP-dependent protein delayed rectifier dependent depolarization effects electrical enhancement enzyme EPSP Figure function ganglion Greengard hippocampal hyperpolarization I-V curve IAHP inactivation increase inhibition input intracellular calcium ion channels ionic Kaczmarek kinetics Levitan M-current mammalian mechanisms membrane potential modulatory molluscan neurons msec muscarinic muscle Natl neuromodulation neuromuscular junction neuron R15 Neurosci neurotransmitters nicotinic acetylcholine receptor norepinephrine outward current patch pathway peptides phosphorylation Physiol postsynaptic potassium channel potassium current presynaptic Proc properties protein phosphorylation pulse recording regulation response role S-channel second messenger sensory neurons serotonin single channel slow EPSP sodium channel sodium current specific spike stimulation substrate synaptic transmitter release Tsien voltage clamp voltage-dependent voltage-dependent calcium channels