Neuromodulation: The Biochemical Control of Neuronal Excitability

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Oxford University Press, 1987 - Medical - 286 pages
This volume provides an introduction to the general principles of neuromodulation--the key neurobiological process for understanding how the brain works. Emphasizing ion channels and biochemical mechanisms of protein phosphorylation, the book shows how neurons regulate their intracellular calcium concentration by modulating the activity of certain ion channels. It goes on to explain the function of intracellular calcium and describes some fascinating neuromodulatory phenomena in the mammalian brain that have long awaited the kind of mechanistic investigations possible in simpler systems. Bridging the gap between neurochemistry and neurophysiology, the authors make complex concepts and research approaches comprehensible to scientists in either field.
 

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Contents

What Is Neuromodulation
3
Substrates
18
How Ion Channel Proteins Work
39
Biochemical Mechanisms That Regulate the Properties
64
Phosphorylation of Purified Ion Channel Proteins
86
The Control of Rhythmic Neuronal Firing
100
Potassium Currents That Regulate Action Potentials
119
Ion Channels Regulated by Calcium
138
Index
281
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About the author (1987)

Leonard K. Kaczmarek is at Yale University. Irwin B. Levitan is at Brandeis University.

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