The Shaping of Life: The Generation of Biological Pattern
Biological development, how organisms acquire their form, is one of the great frontiers in science. While a vast knowledge of the molecules involved in development has been gained in recent decades, big questions remain on the molecular organization and physics that shape cells, tissues and organisms. Physical scientists and biologists traditionally have very different backgrounds and perspectives, yet some of the fundamental questions in developmental biology will only be answered by combining expertise from a range of disciplines. This book is a personal account by Professor Lionel Harrison of an interdisciplinary approach to studying biological pattern formation. It articulates the power of studying dynamics in development: that to understand how an organism is made we must not only know the structure of its molecules; we must also understand how they interact and how fast they do so.
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activator animal apical axolotl biological development biologists boundary Brusselator calcium cell surface Chapter chemistry chemists complex computation concentration concept cotyledons curve D’Arcy Thompson developmental biology dichotomous branching differential diffusion distance diverse Drosophila embryo endoderm equations equilibrium example experimental exponential exponential growth feature Figure gastrulation gene genetic genome Gierer gradient growing tip hemisphere Holloway and Harrison hyphae inhibitor instance interactions involved kind kinetics Lacalli layer Lionel mathematical Meinhardt meristem mesoderm Micrasterias molecular molecules morphogenesis morphogens mutant node non-linear optical resolution organism pattern formation pattern-forming physical physical chemists plots polarization processes protein quantitative rate constants reaction reaction–diffusion reaction–diffusion mechanism region Section segmentation shape shows sine wave single slime mould somite spacing spatial species spherical stage stripes structure substances symmetry t,M J t,M tion tip growth tissue Turing dynamics Turing patterns Turing’s types variability vertebrate waveform wavelength