Inflammatory Disorders of the Nervous System: Pathogenesis, Immunology, and Clinical ManagementAlireza Minagar, J. Steven Alezander A cutting-edge review of the fundamental biological principles underlying the more common inflammatory disorders of the nervous system. The authors provide extensive updates on the latest findings concerning the mechanisms of inflammation and introduce such new concepts and methodologies as "endothelial and leukocyte microparticles" and "gene microarray technology" to help explain important links between the central nervous system (CNS) and general inflammatory processes. Among the diseases examined from an inflammatory perspective are multiple sclerosis, acute disseminated encephalomyelitis, optic neuritis, transverse myelitis, CNS vasculitis, neuropsychiatric systemic lupus erythematosis, Alzheimer's disease, and Parkinson's disease. The role of the immune system in neuroinflammation is also explored in such disorders as neurosarcoidois, HIV-Associated dementia, and HTLV-associated neurological disorders. |
Contents
WINGERCHUK MD Department of Neurology Mayo Clinic College of Medicine | 35 |
Clinical Features Immunopathogenesis and Clinical | 103 |
Clinical Manifestations Pathogenesis and Management | 217 |
and Clinical Management | 257 |
Pathogenesis Immunology and Clinical Management | 291 |
Other editions - View all
Common terms and phrases
abnormalities activation acute disseminated encephalomyelitis ADEM adhesion molecules animals Ann Neurol antibodies antigen associated astrocytes axonal bacterial meningitis blood brain CD4+ CD8+ T cells central nervous system cerebrospinal fluid chemokine chronic Clin clinical correlate corticosteroids cytokines demyelinating diagnosis disease disorders donors dysfunction effects encephalitis endothelial cells experimental autoimmune encephalomyelitis function gene expression glia HAM/TSP IFN-y immune response immunodeficiency Immunol induced infection infiltration inflammation inflammatory inhibit interferon interferon beta-1a interleukin involvement lesions leukocyte levels lymphocytes macrophages mediators mice microglia microparticles mock monocytes multiple sclerosis myelin myelitis myelopathy Neuroimmunol Neurol Sci neurological neuromyelitis optica neurosarcoidosis Neurosci oligodendrocytes onset optic nerve optic neuritis oral pathogenesis pathology patients peripheral progressive protein receptor recipients relapsing role sarcoidosis serum spinal cord studies symptoms syndrome systemic lupus erythematosus therapy tissue treatment trial vasculitis viral virus type vitro West Nile virus