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adenomatous polyps adult polycystic kidney affected person alleles alpha-globin amino acid analysis antigen apoprotein associated autosomal dominant autosomal recessive blood cholesterol chromosomal abnormalities chronic granulomatous disease clinical colon cancer common disease coronary artery disease cystic fibrosis deletion diabetes mellitus diagnosis disease gene disorders DNA probe drome enzyme example familial aggregation familial polyposis familial polyposis coli female fetus fragment length polymorphism frequency g/dL gene therapy genetic component genetic susceptibility glucose hemochromatosis hemochromatosis allele heterogeneity heterozygotes heterozygous HLA haplotypes homozygous human IDDM increased risk inherited insulin LDL receptor Less leukemia leukocyte linkage studies linked loci locus marker allele mendelian mentally retarded mg/dL mmol/L Molecular genetics monozygotic mRNA mutant gene mutations NIDDM offspring oncogene onset parents pedigree pg/mL phenotype plasma polycystic kidney disease population protein recombinant DNA region relatives of patients restriction fragment length result retinoblastoma rheumatoid arthritis screening serum siblings specific tion tissues ug/dL urine variation X chromosome X-linked