Ionic Channels of Excitable Membranes

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Oxford University Press, Incorporated, 1992 - Science - 607 pages
This new, fully revised and expanded edition of Ionic Channels of Excitable Membranes includes new chapters on fast chemical synapses, modulation through G protein coupled receptors and second messenger systems, molecules cloning, site directed mutagenesis, and cell biology. It begins with the classical biophysical work of Hodgkin and Huxley and then weaves a description of the known ionic channels together with their biological functions. The book continues by developing the physical and molecular principles needed for explaining permeation, gating, pharmacological modification, and molecular diversity, and ends with a discussion of channel evolution. Ionic Channels of Excitable Membranes is written to be accessible and interesting to biological and physical scientists of all kinds.

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This the bible equivalent for physiologists interested in ion transport across membranes. If I think of an ion channel and I want a quick and reliable info on that channel, I go and open Hille.

Contents

INTRODUCTION
1
PART I
21
Na AND K CHANNELS OF AXONS
59
CALCIUM CHANNELS
83
POTASSIUM CHANNELS AND CHLORIDE CHANNELS
115
LIGANDGATED CHANNELS OF FAST CHEMICAL SYNAPSES
140
open
154
MODULATION SLOW SYNAPTIC ACTION AND SECOND
170
Cells are coupled by gap junctions
231
PRINCIPLES AND MECHANISMS OF FUNCTION
259
ELEMENTARY PROPERTIES OF PORES
291
COUNTING CHANNELS
315
INDEPENDENCE
337
SATURATION AND BINDING
362
MECHANISMS OF BLOCK
390
STRUCTURE AND FUNCTION
423

Rundown and inactivation could be related to phosphorylation
178
Synaptic action is modulated
186
Encoding is modulated
192
Second messengers are affected by other receptors
199
Mechanotransduction is quick and direct
205
Chemical senses use all imaginable mechanisms
215
Skeletal muscle has ryanodine receptors for Ca2+ release
224
MODIFIERS OF GATING
445
GATING MECHANISMS
472
CELL BIOLOGY AND CHANNELS
504
EVOLUTION AND DIVERSITY
525
REFERENCES
545
INDEX
595
Copyright

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