HIV Molecular Organization, Pathogenicity and TreatmentJohn Morrow, Nancy L. Haigwood It is now 12 years since the first reports of AIDS, and the disease has become a pandemic of devastating proportions. Despite the enormous social, emotional and economic costs, some rays of hope are now visible. Biomedical research into the problems presented by the disease has gained considerable momentum. The discovery of the etiologic agent, the human immunodeficiency virus (HIV), in the mid-1980's has resulted in massive efforts to characterize the organism. In addition the development of new therapies is under intense study and anti-viral and immunomodulating drugs are showing some efficiency in preliminary testing. To date, attempts to produce a protective vaccine have been only partially successful, but these investigations are continuing unabated and we can remain cautiously optimistic that these tremendous efforts may yield some promise in the medium, if not short-term, period. In compiling this volume, the authors have aimed to review key topics in the fast-moving field of HIV research and provide the reader with easy access to current literature and trends in experimentation. |
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Results 1-3 of 40
Page 138
... subunit is derived entirely from the larger subunit ( Fig . 7 ) ( Arnold et al . , 1992 ; Kohlstaedt et al . , 1992 ) . In the heterodimer , p51 has no cleft , and the Asp ' residues are buried and therefore not available for catalysis ...
... subunit is derived entirely from the larger subunit ( Fig . 7 ) ( Arnold et al . , 1992 ; Kohlstaedt et al . , 1992 ) . In the heterodimer , p51 has no cleft , and the Asp ' residues are buried and therefore not available for catalysis ...
Page 144
... subunit , gp120 , is associated with the transmembrane ( TM ) subunit , gp41 , through non - covalent bonds ( Veronese et al . , 1985 ; Gallaher et al . , 1989 ) . Some isolates of HIV - 2 and SIV encode an env gene that is prematurely ...
... subunit , gp120 , is associated with the transmembrane ( TM ) subunit , gp41 , through non - covalent bonds ( Veronese et al . , 1985 ; Gallaher et al . , 1989 ) . Some isolates of HIV - 2 and SIV encode an env gene that is prematurely ...
Page 304
... subunit vaccines Most of the vaccine approaches being tested in humans are recombinant subunit vaccines ( see chapter by Warren and Kennedy , this volume ) . However , in the SIV model , recombi- nant vaccines have by and large failed ...
... subunit vaccines Most of the vaccine approaches being tested in humans are recombinant subunit vaccines ( see chapter by Warren and Kennedy , this volume ) . However , in the SIV model , recombi- nant vaccines have by and large failed ...
Contents
Introduction | 2 |
6 | 12 |
Prevention of opportunistic infections | 20 |
Copyright | |
10 other sections not shown
Common terms and phrases
Acad activity addition AIDS amino acids analysis animals antibodies antigen appears associated binding blood CD4+ cells cellular chimpanzees clinical clones complex contain cytoplasm cytotoxic derived determined directed disease domain effective envelope envelope glycoprotein epitopes et al expression factors function fusion gene genome glycosylation groups HIV infection host human immunodeficiency virus immune immunodeficiency virus type Immunol important individuals induce inhibit initial interaction isolates lentiviruses levels lines lymphocytes macaques mechanism membrane molecular molecules monkeys mutations Natl Nature neutralizing neutralizing antibodies patients peptides present primary primate Proc protection protein receptor recombinant region replication responses Retroviruses reverse transcriptase reviewed role Science sequence shown simian immunodeficiency specific structure studies suggest surface syndrome tested tion transcription transmission vaccine viral virions Virol viruses vitro vivo