Immunobiology: The Immune System in Health and DiseaseThe central thesis of this text is that the immune system exists to protect its host from infection and that its evolutionary history was shaped by this challenge. The first part summarises the basic immunological concepts, the middle three parts deal with main aspects of adaptive immunity, while the final part integrates the material at the level of the complete organism in both health and disease. |
Contents
2127 | 1-6 |
Principles of innate and adaptive immunity | 1-11 |
111 | 1-18 |
Copyright | |
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activation adaptive immune response alleles amino acids anti antibody molecules antigen receptor antigen-binding antigen-presenting cells armed effector assay bacteria binding bone marrow CD4 T cells cell surface cells express Chapter class II molecules clonal co-receptor co-stimulation co-stimulatory complex constant regions cytokines cytosol cytotoxic T cells dendritic cells detected differentiation domains effector T cells endoplasmic reticulum gene rearrangement gene segments genetic graft hapten heavy chains helper T cells human immune system immunogenicity immunoglobulin genes Immunol immunology induce infection inflammatory interactions intracellular isotypes ligand light chains light-chain gene lymphocytes lymphoid tissues macrophages mature membrane MHC class MHC class II MHC molecules mice mouse mutant naive T cells panel pathogens peptides peptides bound polymorphism positive selection produced proliferation proteins recognize recombination red blood cells sequence serum shown signal somatic somatic hypermutation ẞ chain structure T-cell receptor target cell thymic thymocytes thymus transgenic tumor variable regions vesicles