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Ahren allograft allotransplantation Ar'Rajab arginine arginine infusion B-cells basal plasma insulin blood glucose levels Clin clinical collagenase cyclosporine days after diabetes days after transplantation diabetes induction diabetes mellitus diabetic control rats Diabetologia diffusion chambers dose level effects Furthermore glucagon glucagon secretion glucose infusion glucose-induced insulin secretion glucose-stimulated insulin secretion healthy control rats hyperglycemia immunoisolation insulin and glucagon insulin resistance insulin secretion intraportal islet allograft islet function islet graft islet transplantation islets of Langerhans kidney subcapsule Lacy levels of insulin long-term Lund University metabolic mg/kg microencapsulated islets microglobulin Morris PJ nicotinic acid normal number of islets pancreatic islet transplantation pancreatic islets plasma glucose levels plasma insulin levels plasma insulin response plasma levels rat islets renal subcapsular space response to arginine response to glucose restore normoglycemia shown somatostatin Sprague-Dawley streptozotocin administration streptozotocin-diabetic rats transplanted tissue Transplant Proc transplantation of 1000 transplanted islets transplanted rats transplanted with 400 Wistar rat yohimbine