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acid activity addition agents AIDS analysis animals antibodies antigen antiviral appears assay associated binding Biology blood Cancer CD4+ CD8+ cells cellular Center changes Class clinical clones combination complex compounds concentrations containing culture demonstrated detected determined directed disease domain dose drug effect envelope epitopes expression factor function gene HIV infection human immunodeficiency virus immune important increase indicate individuals induced inhibition Institute interaction involved isolates Italy Laboratory levels lymphocytes MAbs mechanism mice Molecular molecules mutations Nature neutralizing normal observed occur patients peptide positive potential present production protein recently receptor recombinant region replication reported Research resistance response reverse role sequence serum showed shown specific strains structure studies suggest syncytia T-cell Table tested therapy tion toxicity transcription treated treatment tumor University vaccine viral vitro vivo Western blot