Marijuana and Madness

Front Cover
David Castle, Robin M. Murray, Deepak Cyril D'Souza
Cambridge University Press, Oct 27, 2011 - Medical
The second edition of this critically acclaimed and award-winning text provides a comprehensive overview of the psychiatry and neuroscience of Cannabis sativa (marijuana). It outlines the very latest developments in our understanding of the human cannabinoid system, and links this knowledge to clinical and epidemiological facts about the impact of cannabis on mental health. Clinically focused chapters review not only the direct psychomimetic properties of cannabis, but also the impact consumption has on the courses of evolving or established mental illnesses such as schizophrenia. Effects of cannabis on mood are reviewed, as are its effects on cognition. This new edition has been extensively updated and expanded with ten new chapters to incorporate major new research findings. This book will be of interest to all members of the mental health team, as well as to neuroscientists, epidemiologists, public health specialists and those involved in drug and alcohol research.
 

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Contents

1 How cannabis works in the brain
1
2 Other cannabinoids
17
3 The function of the endocannabinoid system
23
4 Is cannabis becoming more potent?
35
5 What are the policy implications of the evidence on cannabis and psychosis?
55
6 Cannabis endocannabinoids and neurodevelopment
66
7 The impact of pubertal exposure to cannabis on the brain a focus on animal studies
82
8 Cannabis and cognition short and longterm effects
91
13 Cannabinoids and the cerebellum a potential role in the development of psychosis
144
14 The neural basis for the acute effects of cannabis on learning and psychosis
160
15 Does cannabis use cause schizophrenia? The epidemiological evidence
169
16 Postmortem studies of the brain cannabinoid system in schizophrenia
184
17 The endocannabinoid system in schizophrenia
193
18 The acute effects of cannabinoids in patients with psychotic illness
198
19 Cannabis abuse and the course of schizophrenia
210
20 Understanding cannabis use in schizophrenia
218

9 Does cannabis cause lasting brain damage?
103
10 The association between cannabis use and depression a review of the evidence
114
11 Cannabis cannabinoids and bipolar disorder
129
12 Which cannabis users develop psychosis?
137
21 Addressing cannabis use in people with psychosis
225
Index
234
Copyright

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About the author (2011)

David Castle is Chair of Psychiatry, St Vincent's Hospital and the University of Melbourne.

Sir Robin M. Murray is Professor of Psychiatric Research, Institute of Psychiatry, and Honorary Consultant, South London and Maudsley NHS Foundation Trust, London.

Deepak Cyril D'Souza is Associate Professor of Psychiatry, Director, Schizophrenia Research Program VACHS, and Director, VA-CMHC Schizophrenia Research Clinic, Yale University, Connecticut.

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