Pharmacokinetics for the Pharmaceutical Scientist
Major presentation of pharmacokinetics by a leading international expert. Methods for: estimating drug disposition parameters from data obtained after intravascular or extravascular drug administration, estimating rate and extent of drug bioavailability, and comparing rate and extent of drug availability following administration of several different dosage forms of a drug.
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Simple Linear Models
More Complicated Linear Models
Complicated Linear Models
Linear Multicompartment Disposition
Noncompartmental and System Analysis
Linear Multiple Dose Equations
Simple Nonlinear Models
Administration and Parallel FirstOrder
Relationship between Physiologically
Laplace Derivation of Linear
Measures of Fit
adinazolam amount of drug applied Ar/Vc AUC 0–Inf biexponential Equation bioavailability Biopharm bolus bolus intravenous central compartment cimetidine coefficients curve deconvolution diazepam differential equations digoxin diphenhydramine disposition parameters dosage interval drug concentration elimination rate constant Equa equal estimated parameters Exact Loo-Riegelman example extravascular fitted to Equation flunarizine flurbiprofen free drug given by Equation gives Equation Hence HOURS intersubject C.V. intrasubject kinetics L/min labetalol Laplace transforms least squares linear liver mean metabolism metabolite Method IIIA mg/ml MICHAELIS-MENTEN ELIMINATION Model VIII Model XII Model XXXIX nonlinear ONE-COMPARTMENT OPEN MODEL oral administration penicillamine Pharm Pharmacokinetics physiological plasma concentrations plot prednisolone prednisone rate constant ratio renal clearance SCHEME serum shown in Figure simulated single dose single-dose slope spectinomycin steady steady-state concentration Table theophylline tion tissue TWO-COMPARTMENT OPEN MODEL ug/ml Veng-Pedersen Verapamil versus volume of distribution Wagner-Nelson method warfarin zero zero-order input