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academic acceptance Accessed Address for correspondence Alternatives to Animal animal experimentation animal experiments animal models animal testing animal welfare animals in research Animals Scientific Procedures approach archive aspirin assessment ATLA 23 Available beneﬁts Bill Bill Russell biomedical research Boyd Group CCAC Centre challenge Claire Russell Cleo Paskal Committee cosmetics debate dialogue Dorothy Hegarty Dr Hadwen Trust ECVAM entiﬁc ERGATT established ethical European Festing ﬁeld ﬁnd ﬁrst funding guidelines Hartung Home Ofﬁce Humane Experimental Technique ILAR Journal inbred strains Institute involved Key words London Medical ment mice Michael Balls Michael Festing NC3Rs non-animal organisations outbred stocks primate Principles of Humane programmes progress promoting publication reduction reﬁnement reﬂect regulatory Replacement of Animals role Rowan Russell and Burch scientiﬁc scientiﬁc community scientists signiﬁcant speciﬁc Three Rs concept tiﬁc tion toxicity testing toxicology UFAW University of Nottingham validation vitro W.M.S. & Burch workshop ZEBET