Examination of the Regulation and Function of the Mdm2 Oncogene in Response to the UV LightUniversity of Wisconsin--Madison, 1999 - 171 pages |
Contents
MDM2 induction following treatment | 18 |
Induction of mdm2 transcripts from the P2 promoter | 34 |
Discussion | 47 |
Copyright | |
5 other sections not shown
Common terms and phrases
ability of p53 alternatively spliced amplified antibody BrdU incorporation FITC c-jun cDNA cell cycle cells in G1 cells treated correlates cyclin G DNA content PI DNA replication DNA synthesis dose of UV exon exposure to UV expression of MDM2 fibroblasts flow cytometry following exposure following the high high dose hr after UV immunoprecipitated incubated indirect immunofluorescence induction of MDM2 infected with retroviruses J/m² J/m2 of UV lacking exon levels of MDM2 levels of p53 mdm2 cDNA MDM2 expression mdm2 gene MDM2 induction MDM2 protein mdm2 RNA MEF cells mice mutations NIH3T3 cells NIH3T3 pools normal rates Oncogene overexpressing MDM2 overexpressing p90MDM2 overexpression of MDM2 P2 promoter p53-independent p76MDM2 pBabe primer extension promoter of mdm2 puromycin rates of DNA regulated response to UV retroviruses expressing MDM2 Saucedo stimulate transcription factor transcriptional activation transfected treated with UV treatment with UV tumor UV light UV response UV treatment xeroderma pigmentosum