Gastrointestinal Variables and Drug Absorption: Experimental, Computational and In Vitro Predictive Approaches
MDPI, Mar 19, 2020 - Medical - 206 pages
This book presents some of the state-of-the-art methods for the study of the gastrointestinal variables affecting oral drug absorption. Practical applications of new in vitro release/dissolution methods are presented, as well as in vitro permeability studies to explore segmental differences. The application of MRI methods for the study of colon physiology is presented to illustrate its potential applications in controlled release dosage form design. Some examples of successful in vitro–in vivo correlations show how implementing the gastrointestinal physiological variables in the new in vitro methods can improve the predictions of in vivo drug product performance. The book contains an updated review of the experimental, computational, and in vivo approaches for measuring intestinal permeability.
What people are saying - Write a review
We haven't found any reviews in the usual places.
absorbed absorption acid activity administration amount analysis applications ascending assessment bacteria beads bioavailability calculated cells colon compared compounds concentration Control correlation CrossRef curve determined diffusion digestion dissolution dose drug drug absorption drug delivery effect enzymes equation estimated evaluation experimental experiments extract Figure fimasartan fluid Food forms formulations fraction glucose healthy higher human improved increase intestinal tissue jejunum laponite large intestine levels mean measured medium membrane method microbiota motility observed obtained oral parameters performed perfusion permeability permeation Pharm pharmaceutical pharmacokinetic phase physiological plasma predict presence profiles PubMed rats reference regional release reported represents respectively salt samples segment showed shown significant silico simulated small intestine solubility solution specific subjects swelling Table transport values vitro vivo volume