Handbook of Nuclear Chemistry: Radiochemistry and radiopharmaceutical chemistry in life sciences, Volume 4

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Springer Science & Business Media, 2003 - Engineering - 398 pages
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Impressive in its overall size and scope, this five-volume reference work provides researchers with the tools to push them into the forefront of the latest research. The Handbook covers all of the chemical aspects of nuclear science starting from the physical basics and including such diverse areas as the chemistry of transactinides and exotic atoms as well as radioactive waste management and radiopharmaceutical chemistry relevant to nuclear medicine. The nuclear methods of the investigation of chemical structure also receive ample space and attention. The international team of authors consists of 77 world-renowned experts - nuclear chemists, radiopharmaceutical chemists and physicists - from Austria, Belgium, Germany, Great Britain, Hungary, Holland, Japan, Russia, Sweden, Switzerland and the United States. The Handbook is an invaluable reference for nuclear scientists, biologists, chemists, physicists, physicians practicing nuclear medicine, graduate students and teachers - virtually all who are involved in the chemical and radiopharmaceutical aspects of nuclear science. The Handbook also provides for further reading through its rich selection of references.
 

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Contents

ReactorProduced Medical Radionuclides
1
2 NUCLEAR REACTIONS
3
3 MAIN PRODUCTION APPROACHES WITH NEUTRONS
6
4 TARGETRY
26
5 CHEMICAL PROCESSING
28
6 SHIELDED FACILITIES
29
7 CURRENT REQUIREMENTS AND CHALLENGES
30
9 CONCLUSION
43
99mTc Labeling Chemistry and Labeled Compounds
211
2 GENERAL REQUIREMENTS FOR THE APPLICATION OF 99mTcRADIOPH ARMACEUTICALS
214
3 COMMERCIAL 99mTcRADIOPHARMACEUTICALS
218
4 DIFFERENT TYPES GENERATIONS OF 99mTcRADIOPHARM ACEUTICALS
229
5 STRATEGIES FOR THE LABELING OF TARGETING MOLECULES
231
6 DEVELOPMENTS IN THE LABELING TARGETING MOLECULES
240
7 RECENT DEVELOPMENTS AND FUTURE ROLE OF 99mTcRADIOPHARMACEUTICALS
247
References
248

References
44
Cyclotron Production of Medical Radionuclides
47
2 PRINCIPLES EQUIPMENT AND METHODOLOGY
48
3 PRODUCTION OF POSlTRON EMITTERS
58
4 PRODUCTION OF PHOTON EMITTERS
69
5 PRODUCTION OF THERAPEUTIC RADIONUCLIDES
72
6 CONCLUSIONS AND PERSPECTIYES
75
References
76
Radionuclide Generators
81
2 GENERATORPRODUCED POSITRON EMITTERS
89
3 GENERATORPRODUCED PHOTON EMITTERS
98
4 GENERATORPRODUCED PARTICLE EMITTERS FOR THERAPY
101
5 IN VIVO GENERATORS
106
References
108
11C Labeling Chemistry and Labeled Compounds
119
2 RADIOTRACER SYNTHESIS
120
3 METHODS FOR 11CSYNTHESES
124
4 EXAMPLES OF 11CLABELED COMPOUNDS
144
5 PET IN DRUG DEVELOPMENT
152
6 QUALITY CONTROL OF 11CCOMPOUNDS
156
7 11C AS A TOOL IN CHEMISTRY RESEARCH1
157
18F Labeling Chemistry and Labeled Compounds
167
2 SPECIAL CHARACTERISTICS OF 18FFLUORINE
168
3 METHODS OF 18FFLLORINATION
171
4 18FLABELING OF PEPTIDES AND PROTEINS
193
5 MISCELLANEOUS
200
Further reading
201
References
202
Radioiodination Chemistry and Radioiodinated Compounds
257
2 RADIOISOTOPES OF IODINE FOR LIFE SCIENCES
258
3 RADIOIODINATION OF ORGANIC COMPOUNDS
259
4 RADIOIODINATION OF PEPTIDES AND PROTEINS
268
5 RATING OF RADIOIODINATION METHODS
273
6 EXAMPLES OF CLINICAL APPLICATIONS
275
References
277
Radiometals nonTc nonRe and Bifunctional Labeling Chemistry
279
2 CHOICE AND SYNTHESIS OF BIFUNCTIONAL CHELATORS
282
3 EXAMPLES OF RADIOMETALCHELATE BIOMOLECULE CONJUGATES
300
4 STRUCTURE AND STABILITY OF lRADIOlMETAL COMPLEXES
306
5 OUTLOOK
310
Radionuclide Therapy
315
2 DESIGN OF TARGETED RADIOTHERAPEUTICS
316
3 RADIONUCLIDES FOR TARGETED RADIOTHERAPY
331
References
342
Dosimetry and Biological Effects of Ionizing Radiation
349
2 INTERACTION OF IONIZING RADIATION WITH BIOLOGICAL SUBSTANCES ON MOLECULAR CELLULAR AND TISSUE LEVELS
350
3 DOSIMETRIC QUANTITIES AND UNITS
354
4 MECHANISMS OF EXTERNAL AND INTERNAL EXPOSURE
361
5 HEALTH HAZARDS OF RADIATION EXPOSURE
371
6 DIAGNOSTIC PROCEDURES OF RADIATION INJURIES BIOLOGICAL DOSIMETRY
375
7 MANAGEMENT OF OVEREXPOSURES
379
8 DOSE RESPONSE RELATIONSHIPS
382
References
386
Index
389
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