"first-pass" elimination of some high-clearance drugs following... |
Contents
General introduction and intent of the investigations | 9 |
The use of capillary gas chromatography with SCOT columns | 21 |
Assay of lidocaine in human whole blood plasma and saliva | 39 |
12 other sections not shown
Common terms and phrases
2.0 mg propranolol absorption administration of 30 AUC's avoidance of first-pass ball-valve blood plasma blood samples Boer bypass calculated cannula capillary capillary columns capillary gas chromatography Chromatogr clearance Clin Clintr clonazepam Cmax conc detector determined dosage forms elimination half-lives equation ethanol excretion extraction following i.a. following oral administration following rectal administration gas chromatography gemiddelde glucuronide Gubbens-Stibbe heparinized hepatic high-clearance drugs human plasma i.a. administration infusion injector kinetics lidocaine lidocaine following lidocaine-HCL linear liver log scale mean rectal metabolism ml/min N-methylhexobarbital ng/ml plasma nitrazepam nitrogen selective detection nitroglycerin non-linear obtained oral and rectal oral rectal oxprenolol peak Pharm pharmacokinetic Pharmacol phase plasma blood plasma concentrations ratio rectal and i.a. Rectal bioavailability rectal route rectale toediening rectum route of administration salicylamide SAM-conjugates SAM-Na SAMG SCOT column semi-log scale solid injection system suppository Table Ther tion tmax urine waren Whole blood concentrations µg.min/ml µg/ml